| 大鼠胫骨标准骨折模型的制作 |
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| 引用本文： | 费琴明,陈统一,陈中伟.大鼠胫骨标准骨折模型的制作[J].实验动物与比较医学,2002,22(1):10-12,32. |
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| 作者姓名： | 费琴明 陈统一 陈中伟 |
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| 作者单位： | 复旦大学附属中山医院骨科,上海 200032 |
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| 基金项目： | 中国科学院生物科学与生物技术研究特别支持费课题 (财政部专项 )“人基因组和后基因组研究及开发利用”的资助。编号 :
KJ95T 0 6 |
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| 摘 要： | 为探讨大鼠标准胫骨骨折模型的制作，首先将62只雌性SD大鼠的双侧胫骨髓腔插入9mm直径的医用克氏针，然后通过自行设计制作的骨折造模支架造成胫骨中段闭合骨折，术后通过X线、组织学检查了解骨折类型、移位程度以及骨折的愈合情况。结果术后X线证实横断或短斜型骨折，移位不明显的92例，占总例数的74．4％。组织学检查骨折呈典型的二期愈合过程。通过自制骨折造模支架制作的大鼠径骨横断骨折模型重复性好，外在因素对骨折的影响小，制作简便，符合标准骨折模型的要求。
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| 关 键 词： | 大鼠 胫骨骨折 骨折造模支架 骨折模型 |
| 文章编号： | 1004-8448(2002)01-0010-03 |
| 修稿时间： | 2001/9/28 0:00:00 |
Development of a Standard Closed Fracture in Rat Tibia |
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| FEI Qin-ming,CHEN Tong-yi,CHEN Zhong-wei.Development of a Standard Closed Fracture in Rat Tibia[J].Laboratory Animal and Comparative Medicine,2002,22(1):10-12,32. |
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| Authors: | FEI Qin-ming CHEN Tong-yi CHEN Zhong-wei |
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| Institution: | AO Hong,DING Cheng,LI Chen,XIE Qinglian,QIAO Weiwei 1,JING Naihe 2,ZHAO Guoping,Yang Ping 1,XU Lanwen 1,JIN Meilei |
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| Abstract: | To explore the development of a standard closed fracture in rat tibia, a modified apparatus was designed and tested on 62 female SD rats. The tibia was treated with an intramedullary Steinmann's pin and then was fractured by the apparatus. The fracture type and displacement was observed by X-ray and the fracture healing was detected histologically. The fractures were transverse or transverse with a small oblique component in 92 cases with the success rate 74.2%. Histologically the fracture was healed in secondary. The closed fracture model of rat tibia made by the apparatus is highly reproducible, easy to make, and is a standard model. |
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| Keywords: | Rat Fracture Fracture Apparatus |
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