| 皮肤癌与锰超氧化物歧化酶信号肽基因多态性关系的研究 |
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| 引用本文： | 于波,阎春林,廖康煌. 皮肤癌与锰超氧化物歧化酶信号肽基因多态性关系的研究[J]. 临床皮肤科杂志, 2001, 30(4): 227-229 |
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| 作者姓名： | 于波 阎春林 廖康煌 |
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| 作者单位： | 复旦大学医学院附属华山医院皮肤科 |
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| 摘 要： | 利用聚合酶链式反应与限制性片段长度多态性（PCR－RFLP），检测了52例皮肤癌和50名正常人锰超氧化物歧化酶（MnSOD)信号肽基因的多态性位点V－9A，结果：皮肤癌患者与正常对照相比具有较高的－9A等位基因频率和A／A基因型频率，表明MnSOD信号肽基因的多态性位点V－9A与皮肤癌发病相关。
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| 关 键 词： | 皮肤癌 锰超氧化物歧化酶 聚合酶链式反应－限制性片段长度多态性 PCR－RFLP MnSOD 信号肽基因 基因多态性 |
| 文章编号： | 1000-4963(2001)04-0227-03 |
| 修稿时间： | 2000-12-11 |
Study on the relationship between skin cancer and the genetic polmorphism in the signal sequence of manganese superoxide dismutase(MnSOD) |
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| YU Bo,YAN Chun- lin,LIAO Kang- huang. Study on the relationship between skin cancer and the genetic polmorphism in the signal sequence of manganese superoxide dismutase(MnSOD)[J]. Journal of Clinical Dermatology, 2001, 30(4): 227-229 |
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| Authors: | YU Bo YAN Chun- lin LIAO Kang- huang |
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| Abstract: | PCR- RFLP method was used to detect the polymorphism in the signal sequence of MnSOD gene in 52 patients with skin cancer and 50 nomal controls. The results showed that the frequencies of the- 9A allele and the- 9A/A genotype were higher in skin cancer patients than those in controls, which suggest that the polymorphism in the signal sequence of MnSOD gene is related with the pathogenesis of skin cancer. |
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| Keywords: | Skin cancer Manganese superoxide dismutase Polymerase chain reaction- Restriction fragment length polymorphism |
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