慢性肾炎患者血液流变学、血脂和纤维蛋白原水平及其关系的研究

目的 本文观察了40例慢性肾炎患者血液流变学指标及血脂、纤维蛋白原对其的影响。 方法 检测了40例慢性肾炎患者的全血高切值、全血低切值、血浆粘度、血胆固醇、纤维蛋白原。结果 慢性肾炎患者全血高切值、全血低切值、血浆粘度较正常对照组明显升高 (p<0.005,p<0.001,p<0.005) ,血胆固醇、纤维蛋白原较正常对照组升高 (p<0.01,p<0.05) ,血胆固醇与全血高切粘度成正相关 (r=0.58,p<0.05)。纤维蛋白原与血浆粘度成正相关 (r=0.69,p<0.005)。结论 慢性肾炎患者存在高粘血症 ,血脂、纤维蛋白原在其中起着一定作用。

Changes of hemorheology and their relationship with blood lipid and fibrinogen levels in patients with chronic glomerulonephritis

Objective To study the changes of hemorheology and their relationship with blood lipid and fibrinogen levels in patients with chronic glomerulonephritis. Methods High shear viscosity of blood, low shear viscosity of blood, plasma viscosity, blood cholesterol and fibrinogen in 40 chronic glomerulonephritis patients were detected. Results High shear viscosity of blood, low shear viscosity of blood and plasma viscosity were significantly higher than those in healthy controls (p<0.005, p<0.001, p<0.005 respectively). Blood cholesterol and fibrinogen were higher than those in healthy controls (p<0.05, p<0.01). Fibrinogen was positive correlated to plasma viscosity (r=0.69, p<0.005), blood cholesterol was positive correlated to high shear viscosity (r=0.58, p<0.05). Conclusion There was hyperviscositiemia in the chronic glomerulonephritis. Blood lipid and fibrinogen played some roles in it.