| 慢性重型肝炎患者乙肝病毒C基因变异的初步研究 |
| |
| 引用本文： | 秦波,陈秋云,黄爱龙,任红. 慢性重型肝炎患者乙肝病毒C基因变异的初步研究[J]. 重庆医学, 2004, 33(5): 728-729 |
| |
| 作者姓名： | 秦波 陈秋云 黄爱龙 任红 |
| |
| 作者单位： | 重庆医科大学病毒性肝炎研究所,400010;重庆医科大学附属第二医院核医学科,400010 |
| |
| 基金项目： | 重庆市科委中青年科技专家基金 |
| |
| 摘 要： | 目的探讨乙肝病毒C基因变异与乙型肝炎患者病情的关系.方法用聚合酶链反应(PCR)对2份慢性重型乙型肝炎患者血清及1份乙肝病毒无症状携带者血清进行C基因扩增和克隆,经核苷酸序列分析,与我国HBV克隆株pADR1比较.结果乙肝病毒无症状携带者的C基因与pADR-1的基因相似;而慢重肝患者C基因变异率较高,各有19和14个核苷酸变异.结论乙肝病毒C基因的变异可能与重型肝炎的发生密切相关.
|
| 关 键 词： | 乙型肝炎病毒(HBV) C基因 变异 慢性重型肝炎 |
| 文章编号： | 1671-8348(2004)05-0728-02 |
A preliminary study of hepatitis B virus core gene mutations in chronic severe hepatitis |
| |
| QIN Bo,CHEN Qiu yun,HUANG Ai long,et al.. A preliminary study of hepatitis B virus core gene mutations in chronic severe hepatitis[J]. Chongqing Medical Journal, 2004, 33(5): 728-729 |
| |
| Authors: | QIN Bo CHEN Qiu yun HUANG Ai long et al. |
| |
| Abstract: | Objective To study the effect of hepatitis B virus core gene mutations in chronic severe hepatitis.Methods Hepatitis B virus (HBV) core genes in 2 patients with chronic severe hepatitis and 1 patient with chronic asymptomatic carrier, were analysed by polymerase chain reaction (PCR) direct sequencing approach, and compare with the Chinese HBV pADR 1. Results The HBV core genes in chronic asymptomatic carrier were similar to those in Chinese HBV pADR 1. The core gene mutations in chronic severe hepatitis B infection were more frequently, there were about 16.5 nucleotides variat in a patient. Conclusion HBV core gene mutation may be associated with the pathogenesis of chronic severe hepatitis. |
| |
| Keywords: | hepatitis B virus (HBV) core gene mutation chronic severe hepatitis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
