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Association Study Between the 441C Ins/Del and TaqI A Polymorphisms of the Dopamine D2 Receptor Gene and Alcoholism |
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| Authors: | Hiroki Ishiguro Tadao Arinami Toshikazu Saito Shigeru Akazawa Minoru Enomoto Hiroshi Mitushio Hiroshi Fujishiro Kunimaro Tada Yutaka Akimoto Hideo Mifune Shinichi Shioduka Hideo Hamaguchi Michio Toru Haruo Shibuya |
| Affiliation: | Department of Neuropsychiatry (H.I., M.T., H.S.), Tokyo Medical and Dental University School of Medicine, Tokyo, Japan;Department of Medical Genetics (H.I., T.A., H.H.), Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan;Medical University of Sapporo (T.S.), Hokkaido, Japan;Funabashikita Hospital, (S.A.), Chiba, Japan;Enomoto Clinic (M.E.), Tokyo, Japan;National Hospital of Mental, Nervous and Muscular Disorders (H. Mitsushio), N.C.N.P., Tokyo, Japan;Tokyo Adachi Hospital (H.F.), Tokyo, Japan;Bungosou Hospital (K.T.), Ibaraki, Japan;Rikokai Akimoto Hospital (Y.A.), Chiba, Japan;Hatsuishi Hospital (H. Mifune.), Chiba, Japan;and Saitama Comprehensive Mental Health Center, (S.S.), Saitama, Japan. |
| Abstract: | Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the-141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 Taql A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls ( p < 0.002, odds ratio = 1.82). The Taql A1 allele tended to be more frequent in the alcoholics than in the controls ( p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum δ value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese. |
| Keywords: | Alcoholism Dopamine D2 Receptor Gene Promoter Polymorphism Japanese |