ER、PR及C-erb B-2在乳腺癌原发灶及复发转移灶中的表达及其临床意义

目的研究雌激素受体、孕激素受体及C-erbB-2受体在乳腺癌原发灶和复发转移病灶中的表达差异及其临床意义。方法收集45例经病理确诊的复发乳腺癌患者原发灶组织标本及复发术后组织标本,利用免疫组化法检测ER、PR及C-erbB-2在乳腺癌原发灶和复发转移灶中的表达。结果 ER总的变化率为64.4%（P〈0.05）,其中46.7%的患者ER由阳性转为阴性,另外17.8%的患者ER由阴性转为阳性。PR的总变化率为18.2%（P〈0.05）,由原发灶阳性变为转移灶阴性者占26.7%,另外17.8%患者由阴性转为阳性。C-erbB-2的变化没有统计学差异。结论结果表明在乳腺癌原发灶和复发转移灶之间确实存在着激素受体表达差异的变化,建议尽可能对复发转移乳腺癌病灶重新测定激素受体表达情况,以规范患者诊治,延长患者生存期。

DIFFERENCES IN THE EXPRESSIONS OF ER,PR AND C-ERBB-2 RECEPTOR BETWEEN PRIMARY LESIONS AND METASTATIC LESIONS IN CASES OF BREAST CANCER AND ITS CLINICAL SIGNIFICANCE

Objective To study the differences in the expressions of estrogen receptor（ER）,progesterone receptor（PR）and C-erbB-2receptor between primary lesions and recurrent and metastatic lesions in cases of breast cancer and its clinical significance.Methods The expressions of ER,PR and C-erbB-2receptor between primary lesions and recurrent and metastatic lesions in 45 cases of pathologically confirmed breast cancer were detected through immunohistochemical assaying method.Results The total ER vibration rate was 64.4%（P〈0.05）,and 46.7% of the patients had their ER converted from positive status to negative status,while 17.8%of patients had their ER converted from negative status to positive status.The total PR vibration rate was18.2%（P0.05）,and 26.7%of the patients had their PR converted from positive status to negative status,while 17.8%of patients had their PR converted from negative status to positive status.No statistical difference was found in C-erbB-2status.Conclusion There exist changes in the expressions of hormone receptors between primary lesions and recurrent and metastatic lesions,and it is necessary to reevaluate the status of hormone receptors in recurrent breast cancers to standardize the diagnosis and treatment and to prolong patients＇ survival time.