罗哌卡因用于乳腺癌根治术后硬膜外自控镇痛对呼吸功能的影响

目的 :比较罗哌卡因与布比卡因用于乳腺癌根治术后硬膜外自控镇痛 (PCEA)对术后呼吸功能的影响。方法 :将40例行乳腺癌根治术的患者随机分为2组 ,术后分别用0 2 %罗哌卡因或0 1875 %布比卡因 +吗啡5mg+氟哌啶2 5mg 进行PCEA72h。结果 :视觉摸拟评分和血气分析结果在两组间无显著性差异 (P>0 05) ,但罗哌卡因组呼吸功能的恢复明显优于布比卡因组(P<0 01或P<0 05)。结论 :罗哌卡因用于乳腺癌根治术后PCEA具有与布比卡因相似的镇痛效果 ,但其对呼吸功能的影响较小。

Study on the Sedative Effect of Epidural Ropivacaine on Respiratory Function in Patient after Radical Resection of Breast Carcinoma

OBJECTIVE:To compare the effects between ropivacaine and bupivacaine on respiratory function in self-controlled epidural analgesia in patients after radical resection of breast ocarcinoma.METHODS:Forty patients who had unˉdergone radical operation of mastocarcinoma were randomly divided into2groups and each group were given self-controlled epidural analgesia(PCEA)for72h after administration of0.2%ropivacaine or0.1875%bupivacaine plus5mg of morphine together with2.5mg of droperidol.RESULTS:There were no significant difference between two groups(P>0.05)in visual analogue scales and blood-gas results,but the respiratory recovery function in ropivacaine group was markedly better than that in the bupivacaine group(P<0.01or P<0.05).CONCLUSION:Analgesic effect of ropivacaine in PCEA is similar to that of bupivacaine,but the former has a less effect on the respiratory function of patients.