冠心病患者血同型半胱胺酸和超敏C反应蛋白联合检测的临床意义

目的探讨检测冠心病（CHD）患者血清同型半胱胺酸（Hcy）及超敏c反应蛋白（hs—CRP）的变化与临床的关系。方法将1254例CHD患者分为稳定型心绞痛组（UAP）、稳定型心绞痛组（SAP）和急性心肌梗死组（AMI），以51例健康人作对照，测定HCY及hs—CRP血清含量。结果UAP、SAP及AMI组的HCY及hs—CRP含量明显高于健康对照组，具有明显差异（P〈0．05），且组间差异有统计学意义（P〈0．05）。联合诊断的敏感性和特异性也明显高于单项（P〈0．05）。结论HcyIhs—CRP与CHD患病危险性高度相关，临床联合监测并控制血Hcy及hs—CRP水平对提高CHD的诊断率及预后有重要意义。

Clinical value of combined detection of Homocysteine and high sensitivity C-reactive protein in coronary heart disease

Objective To explore the changes of serum homcysteine（Hcy） and high sensitivity C-reactive protein（hs- CRP） level, and the diagnostic value of combined detection of them in cornary herr disease（CHD）. Methods 125 cases of patients with CHD were divided into three groups of acute myocardial, unstable angina pectoris and stable angina pectoris in comparison with 51 healthy people. Results The concentration of Hcy and hs-CRP in groups of UAP, SAP and SAP significantly was higher in the control group, there were different（P〈0.05）, and there were statistical different among the three groups（P〈0.05）. The sensitivity and specificity of combined higher than each one（P〈0.05）. Conclusion Hcy and hs-CRP were positively correlated with the onset risk of CHD. Combined monitoring and controlling the level of them might be important for improving the diagnosis rate and prognosis of CHD.