维吾尔族高尿酸血症流行病学调查及其相关因素分析

目的：探讨维吾尔族人群中高尿酸血症患病率及其相关因素。方法对新疆维吾尔自治区乌鲁木齐市二道桥片区居民采用整群随机抽样，抽取1302名居民，进行问卷调查、体格检查和实验室检查，了解维吾尔族人群高尿酸血症患病率并分析其相关因素。结果对1302名居民完成调查，其中男592名，女710名，尿酸水平为（235.85±77.06）μmol/L，高尿酸血症患病率为1.9%。男性各年龄段患病率比较差异有统计学意义（P<0.05），女性各年龄段患病率比较差异无统计学意义（P>0.05），男性患病率略高于女性。回归分析显示，性别、舒张压、腰围、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、体重指数、空腹血糖与高尿酸血症密切相关（P<0.05）。结论新疆维吾尔自治区乌鲁木齐市维吾尔族高尿酸血症水平较低。腰围、体重指数、低密度脂蛋白、甘油三酯、胆固醇、空腹血糖是高尿酸血症的危险因素，高密度脂蛋白是高尿酸血症的保护因素。

Epidemiological survey of prevalence of hyperuricemia and its related factors in Uygur population

Objective To investigate the prevalence and related factors of hyperuricemia among Uygur residents in Urumqi,the XinJiang Uygur Autonomous Region. Methods A cross-sectional survey with multiple stage stratified cluster and random sampling was performed. All residents were invited to participate in this survey. Questionnaire, physical examination and laboratory examination were undertaken. Data analysis was performed with SPSS 22.0 for windows statistical package. Results A total of 1302 Uygur residents surveyed, 592 were males and 710 were females. The mean uric acid of the participants was 235.85 ±77.06umol/L. The prevalence of hyperuricemia was 1.9% . The prevalence of males in different ages had different statistically significance. The prevalence of females in different ages had no significant difference. The prevalence of in males was higher than that in females. Logistic regression analysis demonstrated that the prevalence of hyperuricemia was positively correlated with gender, diastolic blood pressure (DBP), waistline, triglyceride (TG), total cholesterol (TC), low-density lipo-protein cholesterol (LDL-C), high-density lipoprotein cholesterol(HDL-C), body mass index(BMI) and fasting blood-glucose(FBG)(P<0.05). Conclusions There was a low prevalence of hyperuricemia among Uygur residents in Urumqi,the XinJiang Uygur Autonomous Region. Waistline, BMI, LDL-C, TG, TC and FBG were the risk factors of hyperuricemia. HDL-C was the protective factor of hyperuricemia.