Fluorouracil (5-FU) induced acute immune haemolytic anaemia |
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| Authors: | P. Sandvei R. Nordhagen T. E. Michaelsen K. Wolthuis |
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| Affiliation: | Department of Medicine, Sarpsborg Hospital, Sarpsborg;Department of Immunology, National Institute of Public Health, Oslo |
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| Abstract: | A female patient on Fluorouracil (5-FU) therapy for rectal carcinoma developed acute intravascular haemolysis with her fifteenth drug injection; a similar episode occurred later after a controlled challenge with the drug. A 5-FU-dependent complement-activating IgM antibody, which reacted with RBC in an indirect antiglobulin test, was detected in her serum. The antibody did not react with cord RBC, but a blood group specificity could not be determined. An excess of 5-FU in the indirect antiglobulin tests resulted in inhibition of these reactions. |
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