| T细胞疫苗、肽疫苗免疫干预自身免疫病的进展 |
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| 引用本文： | 聂红. T细胞疫苗、肽疫苗免疫干预自身免疫病的进展[J]. 免疫学杂志, 2003, 0(Z1) |
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| 作者姓名： | 聂红 |
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| 作者单位： | 上海第二医科大学上海市免疫学研究所 上海 |
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| 摘 要： | 自身反应性T细胞在体内的免疫调节作用主要涉及独特型-抗独特型调节网络。病理性自身反应性T细胞是多发性硬化、类风湿性关节炎等自身免疫病的主要致病原因。本文综述利用这一调节机制治疗自身免疫病的T细胞疫苗和肽疫苗的研究现状和前景。
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| 关 键 词： | 自身反应性T细胞 T细胞疫苗 肽疫苗 多发性硬化 类风湿性关节炎 |
Immune interference to autoimmune diseases by T cell vaccine and peptide vaccine |
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| ME Hong. Immune interference to autoimmune diseases by T cell vaccine and peptide vaccine[J]. Immunological Journal, 2003, 0(Z1) |
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| Authors: | ME Hong |
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| Abstract: | Pathological autoreactive T cells play an important role in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The immune regulation of autoreactive T cells involves in the idiotype anti-idiotypic regulatory network. In this article, we will review the recent advances in T cell vaccine and peptide vaccine in relationship with network regulatory mechanism as a treatment for T-cell-mediated autoimmune diseases. |
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| Keywords: | Autoreactive T cells T cell vaccine Peptide vaccine Multiple sclerosis Rheumatoid arthritis |
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