活性氧在淋巴细胞信号转导中的作用

确切证据表明,活性氧(ROS)参与了淋巴细胞内一系列生理或病理活动的调节。尽管对ROS调节免疫功能的分子机制仅有初步认识,抑制性信号分子如酪氨酸磷酸酶或NF-κB抑制分子I-κB的氧化失活,可能是淋巴细胞内氧化还原信号调节的关键点。根据细胞类型、氧化应激程度及自由基产生的胞内区域的不同,ROS发挥不同生物学效应。本文综述了ROS在淋巴细胞信号转导中的作用,并分析了其在正常和病理免疫应答中可能扮演的角色。

Effect of reactive oxygen species in lymphocyte signaling

Convincing evidence has been provided that reactive oxygen species(ROS) can deliver intracellular signals in lymphocyte either in physiological or pathological status. Although the molecular mechanisms through which ROS regulate immune functions are just beginning to be understood, important events in redox signaling by lymphocytes seem to be represented by oxidative inactivation of inhibitory signaling-molecules such as tyrosine phosphatases or the NF-kB inhibitory molecule I-kB, and elicit a broad array of responses according to the cell type, the oxidative burden and the cellular compartment where radicals are generated. Here some recent and somehow conflicting observations on the involvement of ROS in lymphocyte activity, and propose models for how radical species could contribute to normal and pathological immunity are reviewed.