| 博尔纳病病毒感染的免疫发病机制 |
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| 引用本文： | 徐平.博尔纳病病毒感染的免疫发病机制[J].免疫学杂志,2003(Z1). |
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| 作者姓名： | 徐平 |
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| 作者单位： | 重庆医科大学附属第一医院神经内科 重庆 |
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| 基金项目： | 国家自然科学基金(39870252) |
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| 摘 要： | 博尔纳病病毒(BDV)是单股负链RNA病毒,在体内和体外都缺乏细胞致病性。BDV可引起中枢神经系统持续感染并导致博尔纳病(BD),即免疫介导的脑脊髓炎。浸润的免疫细胞以CD4~ T细胞、CD8~ T细胞、巨噬细胞和B细胞为特征。CD8~ T细胞代表对核蛋白呈抗原特异性的效应细胞群。
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| 关 键 词： | 博尔纳病病毒 免疫学 发病机制 |
Immunopathogenesis of Borna disease virus infection |
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| XU Ping.Immunopathogenesis of Borna disease virus infection[J].Immunological Journal,2003(Z1). |
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| Authors: | XU Ping |
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| Abstract: | The single-stranded RNA Borna disease virus (BDV) , lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease (BD), an immune-mediated encephalo-myelitis. The infiltrating immune cells have been characterized as CD4-positive, CDS-positive T-cells, macrophages and B cells. CD8-positive T cells represent the effector cell population exhibiting antigen specificity for the nucleoprotein. |
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| Keywords: | Borna disease virus Immunology Pathogenesis |
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