| 宫颈癌中端粒酶活性的研究 |
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| 引用本文： | 陆佰荣,廉洁,金明顺,张亮.宫颈癌中端粒酶活性的研究[J].齐齐哈尔医学院学报,2001,22(10):1107-1108. |
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| 作者姓名： | 陆佰荣 廉洁 金明顺 张亮 |
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| 作者单位： | 1. 齐齐哈尔医学院组织胚胎教研室,161042
2. 齐齐哈尔医学院临床医学九六级二班,161042 |
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| 基金项目： | 齐齐哈尔医学院基金资助项目 |
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| 摘 要： | 目的；研究宫颈癌组织及相应癌旁组织中的端粒酶活性，以探讨其作为宫颈癌肿瘤标志物的可能性。方法：采用TRAP法检测20例宫颈癌及相应癌旁组织中的端粒酶活性。结果：20例宫颈癌组织中端粒酶的阳性表达率为80％（16／20），而相应癌旁组织的端粒酶阳性表达率为15％（3／20），两者比较差异有显著性（P＜0．01）。结论：端粒酶是特异性较强的恶性肿瘤基因标志，有可能成为宫颈癌早期诊断和治疗的理想标志物。
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| 关 键 词： | 宫颈癌 端粒酶 活性 无限增殖 病理 |
Study of Telomerase Activity in Cervical Cancer |
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| Sun Xiaojie,et al..Study of Telomerase Activity in Cervical Cancer[J].Journal of Qiqihar Medical College,2001,22(10):1107-1108. |
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| Authors: | Sun Xiaojie |
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| Abstract: | Objective To investigate the telomerase activity in cervical cancer and tumor-adjacent tissues, probe the possibility of telomerase as cervical cancer biological marker.Methods Telomerase activity was detected in 20 cervical cancer and tumor-adjacent tissues with the telomeric repeat amplification protocal(TRAP).Results The positive rate of telomerase activity in 20 cervical cancer was 80% (16/20), however, the positive rate in 20 tumor-adjacent tissues was 15%(3/20), difference was significant, P<0.01.Conclusions Telomerase is a tumor specific gene marker, and may play an important role in early diagnosis and therapy in cervical cancer. |
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| Keywords: | Cervical cancer Telomerase |
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