| 柱晶白霉素及其制剂的有效期预测方法的探讨 |
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| 引用本文： | 程志鹏 张学云. 柱晶白霉素及其制剂的有效期预测方法的探讨[J]. 中国抗生素杂志, 1992, 17(1): 59-62 |
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| 作者姓名： | 程志鹏 张学云 |
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| 作者单位： | 四川抗菌素工业研究所，四川抗菌素工业研究所，四川抗菌素工业研究所，四川抗菌素工业研究所 成都 61OO51，成都 61OO51，成都 61OO51，成都 61OO51 |
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| 摘 要： | 本文通过多组分抗生素降解动力学方程的推导,表明在一般情形下,多组分抗生素的效价变化不能表达为简单级数反应,因此不能用一般动力学方法预测有效期。将初均速法用于含8个以上组分的柱晶白霉素及其制剂的有效期预测,结果与留样考察相近。
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| 关 键 词： | 柱晶白霉素 降解动力学 多组份抗生素 有效期预测 初均速法 |
STUDY ON THE PREDICTING METHOD OF SHELFLSVES OF LEUCOMYCIN AND ITS DOSAGE FORMS |
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| Cheng Zhi-peng,Zhang Xun-yun,Zhao Mao-zeng and Yang Fang. STUDY ON THE PREDICTING METHOD OF SHELFLSVES OF LEUCOMYCIN AND ITS DOSAGE FORMS[J]. Chinese Journal of Antibiotics, 1992, 17(1): 59-62 |
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| Authors: | Cheng Zhi-peng Zhang Xun-yun Zhao Mao-zeng Yang Fang |
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| Abstract: | The degradation equations of antibiotics with more than one components were infered, which showed that the potency change of such kinds of antibiotics couldn't be described by simple reactions in general cases, so that the shelflife couldn't be predicted with usual kinetic methods.The initial average rate method was used to predict the shelflives of leucomycin which contained over 8 components and of its dosage forms, the results obtained were near to,those obtained by observations under room temperature condition. |
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| Keywords: | Leucomycin? Degradation equations Multicomponent antibiotics Prediction of useful life Inifial average rate metbod |
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