Expression of nonclassical MHC class Ib genes |
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Authors: | Howcroft T Kevin Singer Dinah S |
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Institution: | (1) Present address: Experimental Immunology Branch National Cancer Institute, National Institutes of Health, Building 10, Room 5B09, 20892-1360 Bethesda, MD |
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Abstract: | Peptide binding proteins of the major histocompatibility complex consist of the “classical” class Ia and “nonclassical” class
Ib genes. The gene organization and structure/function relationship of the various exons comprising class I proteins are very
similar among the class Ia and class Ib genes. Although the tissue-specific patterns of expression of these two gene families
are overlapping, many class Ib genes are distinguished by relative low abundance and/or limited tissue distribution. Further,
many of the class Ib genes serve specialized roles in immune responses. Given that the coding sequences of the class Ia and
class Ib genes are highly homologous we sought to examine the promoter regions of the various class Ib genes by comparison
to the well characterized promoter elements regulating expression of the class Ia genes. This analysis revealed a surprising
complexity of promoter structures among all class I genes and few instances of conservation of class Ia promoter regulatory
elements among the class Ib genes. |
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Keywords: | MHC Class Ib Promoter Gene expression HLA H2 SLA |
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