| 一例伴有18号长臂等臂染色体的骨髓增生异常综合征的临床和实验观察 |
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| 引用本文： | 陈钟灵,薛永权,杨复,曹幼甫,过宇,谢新,陆定伟. 一例伴有18号长臂等臂染色体的骨髓增生异常综合征的临床和实验观察[J]. 苏州大学学报(自然科学版), 1994, 0(6) |
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| 作者姓名： | 陈钟灵 薛永权 杨复 曹幼甫 过宇 谢新 陆定伟 |
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| 作者单位： | 江苏省血液研究所 |
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| 摘 要： | 报告１例伴有ｉ（１８ｑ）和骨髓纤维化的骨髓增生异常综合征。患者为青年男性,有贫血史十余年,近来脾进行性肿大,骨髓多次干抽。血象示全血细胞减少,有核红细胞显著增多和原粒细胞轻度增加。骨髓涂片和活检示有核细胞增生活跃和涉及三系的病态造血,网状纤维明显增生而无胶原纤维沉着。骨髓细胞染色体Ｒ带核型分析发现,８３％的中期细胞有ｉ（１８ｑ）。患者死于骨髓衰竭所致的严重贫血和出血。我们认为,ｉ（１８ｑ）和骨髓纤维化可能与本例的不良预后有关。
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| 关 键 词： | 骨髓增生异常综合征 i（18q） 诊断 |
AnISochromosomeoftheLongArmofChromsome18inpatientwithMyelodysplasticSyndromewithMyelofibrosis |
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| ChenZhongling,etal. AnISochromosomeoftheLongArmofChromsome18inpatientwithMyelodysplasticSyndromewithMyelofibrosis[J]. Suzhou University Journal of Medical Science, 1994, 0(6) |
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| Authors: | ChenZhongling etal |
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| Abstract: | hisarticlereportsthatapatientofmyelodysplasticsyndrome(MDS)withmyelofibrosisandi-(18q).ThePatientwhoisa29--yeal--oldman,waSnotedtobeanemicover10--years.Recentlythespleenbecameprigressuvektmassiveandbonemarowaspiratesyielded"dytaps"onseveraloccasions.Hematologicalinvestigationdisclosedpancytopenia,numerousnucleatedredcellsandmildiyincreasedmyloblasts(8%)intheperipheralblood.Bonemarrowaspirateandbiopsyrevealedhypercellularmarrow,trilineagemyelodysplasia,significantreticulinfibrosis,,butwithoutcollagenformation.BonemarrowtwotypicanalysiswithR-bandingshowedandisochromosome18qassoleabnormalityintwentyoutof24metaphasesanalysed.Atlast,hediedofsevereanemiaandbleedingduetoboonemarrowfailure.Weconsiderthati(18q)acmyelofibrosismayberelatedtohisPoorprognosis. |
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| Keywords: | Myelodysplasicsyndrome refractoryanemia Myelofibrosis cytogenetics isochromosome |
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