影响肝门部胆管癌术后生存率的多因素分析

目的:探讨影响肝门部胆管癌术后生存率的因素。方法:回顾性分析2001年1月至2011年12月在我科接受手术治疗后出院的90例肝门部胆管癌病人的临床资料,对可能影响生存率的17个因素进行单因素分析,并用COX回归模型进行多因素分析,采用Kaplan-Meier法统计生存率。结果:本研究病人的1、2、3年生存率分别为42.6%、30.0%、22.5%,中位生存时间为10个月。COX回归分析结果显示手术方式与淋巴结转移是影响肝门部胆管癌术后生存率的独立因素。结论:早期发现并进行根治性切除是改善肝门部胆管癌病人预后的关键因素,化疗能提高中、晚期肝门部胆管癌病人的生存率。

Multivariate analysis of survival rates in patients with hilar cholangiocarinoma

Objective To investigate the factors that would affect the survival rate of hilar cholangiocarcinoma. Methods Ninety patients with hilar cholangiocarcinoma in Renji Hospital after surgery between January 2001 to December 2011 were analyzed retrospectively. Univariate analysis was performed to assess the 17 factors, and multivariate analysis with COX proportional hazard regression model. Survival rate was evaluated by Kaplan-Meier method. Results The survival rates of 1, 2 and 3-years in this study were 42.6%, 30.0% and 22.5%. The median survival was 10 months. COX regression analysis revealed that two independent risk factors including surgical type and lymph node metastasis influenced survival rate. Conclusions Diagnosis at early stage of hilar cholangiocarcinoma and radical resection are critical for the prognosis of patients with hilar cholangiocarcinoma. Chemotherapy could improve the survival rate of patients with hi- lar cholangiocarcinoma at advanced and late stage.