| 结直肠癌患者外周血染色体脆性位点研究 |
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| 引用本文： | 杨丹球,陈哲. 结直肠癌患者外周血染色体脆性位点研究[J]. 中国优生与遗传杂志, 2004, 12(2): 26-27 |
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| 作者姓名： | 杨丹球 陈哲 |
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| 作者单位： | 广西钦州市第一人民医院,535000 |
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| 摘 要： | 目的研究结直肠癌的发生机理,期望发现与结直肠癌发生有关的染色体脆性位点,以指导结直肠癌高危人群的筛查和防治.方法对50例结直肠癌患者和50例健康正常人外周血淋巴细胞染色体脆性位点研究.结果50例结直肠癌患者中有32例的染色体结构有异常表达,结构畸变较常累及1号染色体,以1q11,1q21区的裂隙、断裂、重复最为常见,1q21与原癌基因SKI毗邻.结论1q21可能与结直肠癌的发生有关,并对结直肠癌高危人群的筛查和防治有一定的指导意义.
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| 关 键 词： | 结直肠癌 染色体畸变 细胞遗传学 |
| 文章编号： | 1006-9534(2004)02-0026-02 |
| 修稿时间： | 2003-05-17 |
Surrounding blood chromosome fragile sites study on colorectal carcinoma |
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| YANG Dan-qiu,CHEN Zhe.. Surrounding blood chromosome fragile sites study on colorectal carcinoma[J]. Chinese Journal of Birth Health & Heredity, 2004, 12(2): 26-27 |
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| Authors: | YANG Dan-qiu CHEN Zhe. |
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| Abstract: | Objective: To study the cytogenesis of colorectal carcinoma and to look for colorectal carcinoma related to chromosomal fragility sites which could facilitate screening of high risk colorectal carcinoma patients. Methods: 50 cases of colorectal carcinomas and 50 healthy men surrounding blood lymphocytes were analysed chromosomal fragility sistes. Results: Among the 50 cases of colorectal carcinomas, there are 32 cases of chromosome structural abnormalities. The most frequently found structural abnormalities in colorectal carcinoma were breakpoint 1q11 and 1q21. 1q21 neighboring locus was original carcinoma gene SKI. Conclusion: The results suggest that breakpoint 1q21 may be related to tumorgenesis and may be useful in screening and preventing colorectal carcinoma. |
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| Keywords: | Intestinal neoplasms chromosome aberrations cytogenetics |
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