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碳增强的聚醚醚酮作为髋臼假体材料的实验研究
引用本文:贾庆卫,孙俊英,江宏卫,孙康,王禹基.碳增强的聚醚醚酮作为髋臼假体材料的实验研究[J].中国矫形外科杂志,2003(Z1).
作者姓名:贾庆卫  孙俊英  江宏卫  孙康  王禹基
作者单位:江苏苏州大学第一附属医院骨科,江苏苏州大学第一附属医院骨科,江苏苏州大学第一附属医院骨科,上海交通大学复合材料研究所,江苏苏州大学第一附属医院骨科 215006,215006,215006,215006
基金项目:卫生部科学研究基金(98-1-325)
摘    要:目的:评价碳纤维增强的聚醚醚酮(CFPEEK)作为髋臼假体材料的生物相容性和耐磨损性。方法:(1)采用国产材料和工艺研制出碳纤CFPEEK复合材料,在模拟体液环境下对其本身以及与不同磨擦偶的耐磨损性能进行测试,并与传统髋臼假体材料超高分子聚乙烯(UHMWPE)作比较。(2)体外研究CFPEEK磨屑对巨噬细胞ANA-1释放白细胞介素1(IL-1_β)和肿瘤坏死因子α(TNF-α)的影响,并与传统的人工关节材料比较,以确定各材料间生物学反应的差异。结果:(1)CFPEEK的体积磨损率只为UHMWPE的1/2,耐磨损性能明显优于UHMWPE(Alpha=0.01水平)。CFPEEK与钴铬钼合金(CoCrMo)对磨将产生最少的磨屑(Alpha=0.01水平)。CFPEEK与CoCrMo对磨时的摩擦系数最低。(2)各实验组IL_(-1β)和TNF-α的释放都有增高,实验结果总体差异有显著性意义(P=0.0001),UHMWPE组明显高于CFPEEK组(Alpha=0.01水平)。结论:CFPEEK材料具耐磨损、生物相容性好的特点,是一种未来髓臼假体的理想材料。

关 键 词:髋臼  生物相容性材料  磨损  体外研究

Carbon Fiber Composite for Acetabular Prosthesis-Fabrication, Wear and Biocompatibility
JIA Qing-wei,SUN Jun-ying,JIANG Hong-wei,et al..Carbon Fiber Composite for Acetabular Prosthesis-Fabrication, Wear and Biocompatibility[J].The Orthopedic Journal of China,2003(Z1).
Authors:JIA Qing-wei  SUN Jun-ying  JIANG Hong-wei  
Institution:JIA Qing-wei,SUN Jun-ying,JIANG Hong-wei,et al. Department of Orthopaedics,The First Hospital of Suzhou University,Suzhou 215006
Abstract:Objective: To observe the biocompatibility and wear properties of carbon fiber reinforced polyetheretherketon composite(CFPEEK) materials used as acetabular prosthesis. Methods: (1)Domestic PEEK and advanced molding methods were used to develop a kind of CFPEEK. Test its wear properties in a simulated in vivo enviroment. The results were compared with traditional acetabular material UHMWPE. (2)The macrophage strain ANA- 1 has been cultured with CFPEEK debris for 2 hours. Estimate the interleukin- 1(IL-1) and tumor necrosis factor alpha(TNF-a)made by the cells. The results were compared with traditional prosthetic materials to demonstrate the different biologyical reactions. Results: (1)The specific wear rate of CFPEEK was only 1/2 of the specific wear rate of UHMWPE, Meaning that the wear property of CFPEEK is better than that of UHMWPE (Alpha = 0.01 level). Weared with cobalt-chromium-molybdenum alloy (CoCrMo) CFPEEK will produce the lest amount of debris (Alpha = 0.01 level) and demonstrated the lowest friction coefficient. (2) All kinds of debris in this study can activate ANA -1. UHMWPE debris can make macrophage to produce more IL -1 and TNF - a than CFPEEK debris( Alpha = 0.01 level). Conclusion: The results of this experiment show that CFPEEK have good biocompatibility,better wearing characteristics and lower moduli of elasticity. It is a promising biological composite material for acetabular prosthesis.
Keywords:Acetabulum  Biocompatible materials  Wear  In vitro experiment  
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