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| 纳米羟基磷灰石急性毒性试验研究 | |
| 引用本文： | 汤京龙,王硕,王建宇,刘丽,李佳戈,苑富强,陆颂芳,周红娇,奚廷斐.纳米羟基磷灰石急性毒性试验研究[J].北京生物医学工程,2008,27(4):337-340. |
| 作者姓名： | 汤京龙 王硕 王建宇 刘丽 李佳戈 苑富强 陆颂芳 周红娇 奚廷斐 |
| 作者单位： | 1. 北京科技大学材料学院,北京,100053;中国药品生物制品检定所,北京,100050 2. 中国药品生物制品检定所,北京,100050 3. 云南省医疗器械检验所,昆明,650034 |
| 摘 要： | 对纳米羟幕磷灰石(nano-HAP)进行急性毒性试验研究,为长期毒性试验和其他毒理学试验提供参考依据,并初步了解nano-HAP进入血液循环系统后,是否会迁移到其它器官和组织.实验选用清洁级的110～130g Wistar大鼠70只,分为7组,实验组各组剂量分别为21.66mg/kg、29.97 mg/kg、41.49 mg/kg、57.42 mg/kg、79.48 mg/kg、110.39 mg/kg,以生理盐水为对照组.单次尾静脉注射,14d内观察动物的毒性症状,记录动物死亡情况.将死亡动物解剖,对动物主要脏器进行病理组织学检查.结果显示nano-HAP在Wistar大鼠身上尾静脉注射时LD50为51.79 mg/kg,由病理结果推测实验动物的死亡原因是由血管栓塞所致.在一只最低剂量组死亡动物肝的汇管区及附近肝内有占位性蓝染无定型物,肝内灶性炎细胞浸润.说明nano-HAP颗粒在充分分散的情况下会通过血液循环进入到身体其它器官,因此有必要对nano-HAP的生物安全性进行进一步研究. |
| 关 键 词： | 纳米 羟基磷灰石 急性毒性 |
Study on the acute toxicity of nano-hydroxyapatite |
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| TANG Jinglong,WANG Shuo,WANG Jianyu,LIU Li,LI Jiage,YUAN Fuqiang,LU songfang,ZHOU Hongjiao,XI Tingfei.Study on the acute toxicity of nano-hydroxyapatite[J].Beijing Biomedical Engineering,2008,27(4):337-340. | |
| Authors: | TANG Jinglong WANG Shuo WANG Jianyu LIU Li LI Jiage YUAN Fuqiang LU songfang ZHOU Hongjiao XI Tingfei |
| Institution: | TANG Jinglong1,2,WANG Shuo2,WANG Jianyu2,LIU Li2,LI Jiage2,YUAN Fuqiang2,LU songfang2,ZHOU Hongjiao3,XI Tingfei2 1 Material Science College,University of Science , Technology Beijing,Beijing 100083,2 National Institute for the Control of Pharmaceutical & Biological Product,Beijing 100050,3 Institute for the Control of Medical Devices of Yunnan Province,Kunming 650034 |
| Abstract: | To explore the acute toxicity of nano-hydroxyapatite(nano-HAP),and establish a dosage regimen for subacute/subchronic and other toxicological studies as well as to provide primary information on the mode of translocation for nano-HAP in circulatory system.Acute toxicity test were carried out.70 Wistar rats were divided into 7 groups at random,control group used saline and 6 treated groups,their dosages used were 21.66mg/kg,29.97 mg/kg,41.49 mg/kg,57.42 mg/kg,79.48 mg/kg,110.39 mg/kg respectively,which were ... |
| Keywords: | nano hydroxyapatite acute toxicity |
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