芪明颗粒对单纯型糖尿病视网膜病变患者视网膜功能的影响

目的：探讨芪明颗粒对单纯型糖尿病视网膜病变患者视网膜功能的影响。
　　方法：选取2012－05／2014－05在我院就诊的80例单纯型视网膜病变患者，随机分为两组，每组40例。对照组：在常规治疗基础上给予复方血栓通胶囊治疗。观察组：在常规治疗基础上给予芪明颗粒治疗。
　　结果：观察组患者总有效率为95％高于对照组患者总有效率80％，差异具有统计学意义（ P＜0．05）。治疗后，观察组患者视野平均敏感度高于对照组患者视野平均敏感度，差异具有统计学意义（P＜0．01）；观察组患者O1，O3潜伏期与对照组患者O1，O3潜伏期比较，差异具有统计学意义（P＜0．05）；观察组患者O1，O3，O4振幅与对照组患者O1，O3，O4振幅比较，差异具有统计学意义（P＜0．01）；观察组患者纤维蛋白原、全血黏度低切、血浆黏度、全血黏度指标低于对照组患者纤维蛋白原、全血黏度低切、血浆黏度、全血黏度指标，差异具有统计学意义（P＜0．01）；观察组患者总胆固醇、低密度脂蛋白胆固醇指标低于对照组患者总胆固醇、低密度脂蛋白胆固醇指标，差异具有统计学意义（P＜0．05）；观察组患者血清胰岛素样生长因子－1及血管内皮生长因子水平低于对照组患者血清胰岛素样生长因子－1及血管内皮生长因子水平，差异具有统计学意义（P＜0．01）。
　　结论：芪明颗粒可延缓单纯型糖尿病视网膜病变的进展，对早期糖尿病性视网膜病变有较好的防治作用，能改善患者视网膜功能。

Qi Ming granule intervention on retinal function in the patients with simplex diabetic retinopathy

AIM: To study the effect of Qi Ming granule intervention on retinal function in the patients with simplex diabetic retinopathy.

METHODS: Eighty cases of simple diabetic retinopathy patients in our hospital from May, 2012 to May, 2014 were randomly divided into two groups, and each group had 40 cases. The control group was received conventional treatment combined with compound Xueshuantong capsule. The observation group was given conventional treatment combined with Qi Ming granule treatment.

RESULTS: The total efficiency(95%)of the observation group was higher than that(80%)of the control group, and there was statistically significant difference(P<0.05). After treatment, visual field mean sensitivity of the observation group was higher than that of the control group, and there was statistically significant difference(P<0.01). After treatment, patients with O₁ and O₃ latency, the observation group was compared with the control group, and there was statistically significant difference(P<0.05). After treatment, patients with O₁, O₃, and O₄ amplitude, the observation group was compared with the control group, and there was statistically significant difference(P<0.01). After treatment, fibrinogen and blood viscosity of low shear, plasma viscosity, and whole blood viscosity of the observation group were lower than those in the control group, and there were statistically significant differences(P<0.01). After treatment, total cholesterol and low density lipoprotein cholesterol of the observation group was less than those in the control group, and there were statistically significant differences(P<0.05). After treatment, the patients in the observation group serum insulin-like growth factor-1 and vascular endothelial growth factor serum insulin levels were lower than those of the control group of patients, and there were statistically significant differences(P<0.01).

CONCLUSION: Qi Ming granule can delay the progress of the simplex diabetic retinopathy, and it has a good effect on the treatment of early diabetic retinopathy and can improve the function of retina.