重视糖尿病与癌症关系的研究

糖尿病,尤其是2型糖尿病,易并发癌症,主要是胰腺癌、肝癌、结肠直肠癌、乳腺癌、子宫内膜癌等,且致死亡率增加,其确切原因不明.可能与高胰岛素血症及胰岛素样生长因子的促生长及促有丝分裂作用有关.最近对某些长效胰岛素类似物的这一作用提出疑问,但目前尚无可靠证据证明这一点.二甲双胍似可能有保护作用.

Pay more attention to the study of the relationship between diabetes mellitus and cancer

Diabetic patients are at increased risk of some cancers,mainly pancreatic cancer,liver cancer,colorectal cancer,breast cancer,endometrial cancer,etc.,and these cancers often result in higher mortalities than that in nondiabetics.The exact mechanism of this relationship is still unclear.The most suggested factor are hyperinsulinemia and insulin-like growth factors with their growth promoting and mitogenic effects.Recently,some insulin analogues are suspected to have these carcinogenic effects,but no firmly proven data are available yet.Metformin may have a protective effect in this regard.