| 氟烷致肝线粒体膜内脂质成分改变的实验研究 |
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| 引用本文： | 隋波,俞卫锋,张广明. 氟烷致肝线粒体膜内脂质成分改变的实验研究[J]. 中华肝脏病杂志, 1998, 6(2): 93-95 |
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| 作者姓名： | 隋波 俞卫锋 张广明 |
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| 作者单位： | 济南军区总医院麻醉科，第二军医大学东方肝胆外科医医院麻醉科，第二军医大学药学院，第二军医大学基础部生化教研室，第二军医大学长海医院麻醉科 |
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| 摘 要： | 目的探讨氟烷性肝炎的发病机理。方法将传统吸人麻醉药氟烷与新吸入麻醉药七氟醚对比，用高压液相技术分析肝线粒体膜磷脂在麻醉药作用后的脂质成分改变。结果氟烷在低浓度即可使肝线粒体主磷脂降解，溶血卵磷脂增加，在高浓度时有不可逆转的肝细胞损伤作用；而七氟醚只有主磷脂降解。溶血卵磷脂增加的倾向。结论氟烷致肝线粒体脂质改变可能为氟烷性肝炎的根本原因。
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| 关 键 词： | 氟烷，肝线粒体，高压液相，肝炎 |
EXPERIMENTAL RESCARCH ON PHOSPHOLIPIDS VARIATION OF HALOTHANE ON LIVER MITOCHONDRIA |
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| Sui Bo, Yu Weifeng, ZhangGuangming,et al.. EXPERIMENTAL RESCARCH ON PHOSPHOLIPIDS VARIATION OF HALOTHANE ON LIVER MITOCHONDRIA[J]. Chinese journal of hepatology, 1998, 6(2): 93-95 |
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| Authors: | Sui Bo Yu Weifeng ZhangGuangming et al. |
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| Affiliation: | Sui Bo, Yu Weifeng, ZhangGuangming, et al. Department of Anesthesia, Jinan Military General Hospital, Jinan 250031. |
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| Abstract: | Objective To study the pathogenesis of halothane hepatotoxicity. Methods By using high performance liquid chromatography (HPLC) technology the effects of different concen- trtions of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed. Results Halothane in low concentration have the functions to mitochondria membrane major phospholipids degradation and increases lysophosphatidylcholive, that in high concentration halot hane damages mitochondria membrane irreversibly and sevoflurane only has a tropism of major phospho-lipids degradation and increases lysophosphotidylcholive. Conclusion The pathogenesis of halthane hepatotoxicity was the phospholipids variation on liver mitochondria . |
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| Keywords: | Halothane Liver Mitochondria HPLC Hepatitis |
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