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Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase,causes severe infantile onset leukoencephalopathy
Authors:Benjamin E. Theisen  Anastasia Rumyantseva  Julie S. Cohen  Wendy A. Alcaraz  Deepali N. Shinde  Sha Tang  Siddarth Srivastava  Jonathan Pevsner  Aleksandra Trifunovic  Ali Fatemi
Affiliation:1. Hugo W. Moser Research Institute at Kennedy Krieger, Kennedy Krieger Institute, Baltimore, Maryland;2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland;3. Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), Center for Molecular Medicine and Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, Cologne, North‐Rhine Westfalia, Germany;4. AmbryGenetics, Aliso Viejo, California;5. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland;6. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Abstract:
Keywords:aminoacyl tRNA synthetase  aminoacylation  brain  intellectual disability  leukoencephalopathy  mitochondria
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