| 卵巢癌组织表达人源性单克隆抗体识别的肿瘤相关抗原 |
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| 引用本文： | 邬淑云 易为民 等. 卵巢癌组织表达人源性单克隆抗体识别的肿瘤相关抗原[J]. 江西医学院学报, 1998, 38(2): 1-4 |
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| 作者姓名： | 邬淑云 易为民 等 |
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| 作者单位： | Wu Shuyun Wen Gansheng Xu Fangyun Liu Qiuru Gong Wenhua Yu Ying (Department of Pathophysiology and Tumor Immunology Research，Jiangxi Medical College，Nanchang 330006 |
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| 基金项目： | 国家自然科学基金,江西省自然科学基金 |
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| 摘 要： | 应用抗卵巢癌人源性单克隆抗体（ＭｃＡｂ）ＡＴ４对人卵巢肿瘤进行免疫组织化学分析，以观察ＡＴ４识别的肿瘤相关抗原在人卵巢癌组织中表达的发生率和意义。所用材料为福尔马林固定和石蜡包埋的活检标本。切片经过氧化物酶抗过氧化物酶（ＰＡＰ）染色。结果发现：原发性卵巢癌的ＭｃＡｂＡＴ４免疫组织化学染色的阳性率为５／６，转移性卵巢癌为３／６，良性卵巢肿瘤为３／２１。本研究结果表明，人源性ＭｃＡｂＡＴ４识别的肿瘤相关抗原ＣＡＴ４是卵巢癌的免疫组化标记
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| 关 键 词： | 人源性单克隆抗体 免疫组织化学 卵巢癌 肿瘤相关抗原 |
Ovarian Cancer Tissues Express Tumor Associated Antigen Recognized by Human Monoclonal Antibody |
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| Wu Shuyun Wen Gansheng Xu Fangyun Liu Qiuru Gong Wenhua Yu Ying. Ovarian Cancer Tissues Express Tumor Associated Antigen Recognized by Human Monoclonal Antibody[J]. Acta Academiae Medicinae Jiangxi, 1998, 38(2): 1-4 |
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| Authors: | Wu Shuyun Wen Gansheng Xu Fangyun Liu Qiuru Gong Wenhua Yu Ying |
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| Abstract: | In this article,a human monoclonal antibody AT 4 to ovarian carcinoma was used for immunohistochemical analysis of human ovarian tumor to investigate the incidence and significance of the expression of the tumor associated antigen recognized by McAb AT 4 in human ovarian cancer tissues. Peroxidase antiperoxidase(PAP) staining was performed on formalin fixed,paraffin embedded biopsy specimens.It was reported that positive staining with McAb AT 4 was detected in 5 of the 6 primary ovarian carcinomas, 3 of 6 metastatic ovarian cancers,and 3 of 21 benign ovarian tumors.It is indicated that the tumor associated antigen CAT 4 is an immunochemical marker of human ovarian carcinoma. |
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| Keywords: | human monoclonal antibody immunohistochemistry ovarian carcinoma tumor associated antigen |
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