非小细胞肺癌患者血清血管内皮生长因子、血小板衍生生长因子和表皮生长因子受体测定的临床意义

目的 探讨血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、血小板衍生生长因子(platelet-derived growth factor,PDGF)和表皮生长因子受体(epidermal growth factor receptor,EGFR)测定在非小细胞肺癌(non-small cell lung cancer,NSCLC)诊断和预后判定中的意义.方法 采用双抗体夹心ABC-ELISA法测定31例NSCLC患者及30名健康者血清VEGF、PDGF和EGFR的含量.结果 NSCLC患者血清VEGF、PDGF和EGFR测定值均高于健康对照组(P值均＜0.01).血清VEGF、PDGF和EGFR测定值与NSCLC病理分型无关(P值均＞0.05),与远处转移有关,远处转移组的测定值高于未转移组(P＜0.05～0.01).NSCLC患者血清VEGF与PDGF测定值之间呈显著正相关(r=0.641,P＜0.01),血清VEGF和EGFR测定值呈正相关(r=0.369,P＜0.05).结论 检测血清VEGF、PDGF和EGFR水平对NSCLC的诊断和预后判定具有一定价值.

Clinical assay of serum vascular endothelial growth factor,platelet-derived growth factor and epidermal growth factor receptor in patients with non-small cell lung cancer

Objective To explore the diagnosis and prognosis effect of the serum vascular endothelial growth factor,platelet-derived growth factor and epidermal growth factor receptor in non-small cell lung cancer(NSCLC).Methods The sandwich enzyme-linked immunoabsorbent assay was used to detect serum VEGF,PDGF and EGFR in patients with NSCLC.Results Compared with healthy control group,the levels of serum VEGF.PDGF and EGFR in NSCLC patients were much higher.The serum VEGF,PDGF and EGFR levels were not correlated with pathological style.The serum VEGF,PDGF and EGFR levels in metastasis group were higher than those in group without metastasis.The serum VEGF level was positively correlated with the serum PDGF level and EGFR level.Conclusions The detection of serum VEGF and PDGF has very important value in estimating NSCLC diagnosis and prognosis.