瑜伽对乳腺癌化疗患者癌因性疲乏的干预效果

目的：了解乳腺癌化疗患者癌因性疲乏状况，探讨瑜伽对患者癌因性疲乏的干预效果。方法：制作乳腺癌患者康复瑜伽；采用癌症疲乏量表(cancer fatigue scale，CFS)将第2次入院化疗且存在疲乏(CFS总分>0)的乳腺癌患者100例随机分为实验组和对照组各50例。对照组给予乳腺科常规治疗护理，实验组除常规治疗护理外进行有规律的瑜伽练习，为期4个月，于第2，4，6次化疗时收集患者CFS评价情况，比较两组癌因性疲乏的状况。结果：最终有效病例82例，其中实验组40例，对照组42例。82例患者躯体疲乏得分(12.67±3.46)相对较高，干预前两组的CFS总分及3个维度得分差异均无统计学意义(P>0.05)；干预后第4次化疗实验组疲乏总分、躯体疲乏得分均低于对照组，差异有统计学意义(P<0.05)；干预后第6次化疗实验组疲乏总分、躯体疲乏得分、认知疲乏得分均低于对照组，差异有统计学意义(P<0.05)；重复测量方差分析发现两组患者总体疲乏、躯体疲乏、认知疲乏得分的干预主效应差异有统计学意义(P<0.05)，总体疲乏、躯体疲乏、情感疲乏得分的时间主效应差异有统计学意义(P<0.05)，总体疲乏、躯体疲乏、认知疲乏得分的干预因素与时间因素存在交互作用(P<0.05)。结论：乳腺癌化疗患者躯体疲乏较重，瑜伽干预能有效缓解乳腺癌化疗患者的躯体疲乏和认知疲乏，从而降低总体疲乏程度。

Effect of Yoga on cancer related fatigue in breast cancer patients with chemotherapy

Objective: To evaluate the condition of cancer-related fatigue (CRF) in breast cancer patients withchemotherapy and to explore the effect of Yoga on it.Methods: After the completion of Yoga, 100 breast cancer patients with CRF (CFS>0) wereselected and were randomly divided into the Yoga group and the control group (n=50). Patientsin the control group only received routine cure and care while patients in the Yoga group receivedextra Yoga exercise, lasting for 4 months. Cancer fatigue scale (CFS) was evaluated in the 2nd, 4thand 6th round of chemotherapy.Results: At the end, 82 cases qualified for the study, 42 cases for the control group and 40 for theYoga group. The mean score of body fatigue was 12.67±3.46. There was no significant difference inCRF between the Yago group and the control group before the Yoga intervention (P>0.05). Afterthe 4th round of chemotherapy, the mean scores of CFS and body fatigue in the Yoga group weresignificantly lower than that in the control group (P<0.05). After the 6th round of chemotherapy,the mean scores of CFS, body fatigue and cognitive fatigue in the Yoga group were lower than thatin the control group (P<0.05). Repeated analysis of variance showed that the difference in theoverall fatigue, body fatigue and cognitive fatigue between the Yoga group and the control groupwas significant (P<0.05); the time influence on the overall fatigue, body fatigue and emotionalfatigue was significant difference between the 2 groups (P<0.05); there were interactions betweenthe effect of Yago and time on the overall fatigue, body fatigue and cognitive fatigue (P<0.05).Conclusion: The body fatigue was more serious in breast cancer patients with chemotherapy.Yoga intervention could significantly reduce body fatigue, cognitive fatigue, thus reduce the overallfatigue in breast cancer patients with chemotherapy.