| 糖皮质激素与骨 |
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| 引用本文： | 李京宝,蔺潇,周虹.糖皮质激素与骨[J].中华骨质疏松和骨矿盐疾病杂志,2013(4):283-292. |
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| 作者姓名： | 李京宝 蔺潇 周虹 |
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| 作者单位： | 悉尼大学ANZAC研究所骨生物学研究部;西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室;特殊环境生物物理学研究所; |
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| 基金项目： | 国家留学基金管理委员会公派访问学者项目(201203070074) |
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| 摘 要： | 糖皮质激素在临床上应用广泛,但所致的骨质流失、代谢失调等不良反应也限制了其使用.本文对糖皮质激素对骨及其细胞的生理和病理生理作用进行综述,并对其不良反应发生的分子机制进行讨论.
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| 关 键 词： | 糖皮质激素 骨 生理作用 病理生理作用 骨质疏松 |
Glucocorticoids and bone |
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| LI Jing-bao,LIN Xiao,ZHOU Hong.Glucocorticoids and bone[J].Chinese Journal of Osteoporosis and Bone Mineral Research,2013(4):283-292. |
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| Authors: | LI Jing-bao LIN Xiao ZHOU Hong |
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| Institution: | 1. Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, NSW2139, Australia ; 2. Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi＇an 710072, China |
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| Abstract: | Glucocorticoidsare effective in treating numerous conditions but their use is limited by side effects such as bone loss or metabolic dysfunction. This article reviews the physiology and pathophysiology of glucocorticoid action on bone cells and discusses current and emerging concepts regarding the molecular mechanisms underlying glucocorticoid off-target effects. |
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| Keywords: | glucoeorticoids bone physiology pathophysiology osteoporosis |
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