膀胱移行细胞癌survivin表达及与bcl-2的相关性

目的：探讨凋亡抑制蛋白survivin在膀胱移行细胞癌中的表达及其与bcl-2蛋白表达的相关性。方法：应用免疫组化方法，检测43例膀胱移行细胞癌标本中survivin、bcl-2蛋白的表达，15例正常膀胱黏膜移行上皮进行对照研究。结果：43例膀胱移行细胞癌组织中，survivin蛋白阳性表达率为67．4％，而正常膀胱黏膜组织中未见survivin蛋白阳性表达。survivin蛋白表达与膀胱移行细胞癌临床分期、病理分级相关。survivin蛋白与bcl-2蛋白表达负相关（P〈0．01）。结论：survivin基因可通过抑制膀胱移行癌细胞凋亡，对膀胱移行细胞癌的发生发展起作用。

Expression of Survivin and bcl-2 in Transitional Cell Carcinoma of Bladder

Objective:To study the expression of apoptosis related gene survivin and its relation with expression of bcl-2 protein in transitional cell carcinoma of the bladder(BTCC).Methods:The expression of survivin and bcl-2 was detected by SP immunostaning technique in 43 cases of transitional cell carcinoma of the bladder,and correlation during them was analyzed,and compared with that in 15 cases of normal bladder specimens.Results:In 43 cases of transitional cell carcinoma of the bladder,the positive rate of survivin protein was 67.4%,but in 15 cases of normal bladder specimens,none could be detected the positive expression of survivin protein.Expression of survivin protein was detected in a significantly greater proportion of BTCC than normal bladder specimens.There was relationship between survivin protein expression and tumor grades.Expresson of bcl-2 was negative correlated with expression of survivin protein.Conclusion:Survivin gene may play an important role in pathogenesis of BTCC.