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| 相转移催化剂在盐酸氟桂利嗪合成中的应用 | |
| 引用本文： | 龚子东,孟祥涛,张香菊,李晓燕.相转移催化剂在盐酸氟桂利嗪合成中的应用[J].河南大学学报(医学版),2006,25(2):24-25. |
| 作者姓名： | 龚子东 孟祥涛 张香菊 李晓燕 |
| 作者单位： | 1. 河南省医药学校,河南,开封,475001 2. 河南省工艺美术学校,河南,郑州,450000 3. 开封市龙海医院,河南,开封,475003 |
| 摘 要： | 目的:研究相转移催化剂十六烷基三甲基溴化铵(CTMAB)对合成盐酸氟桂利嗪的影响。方法:用肉桂基哌嗪和二氟苯基溴甲烷为原料,以二氯甲烷为溶剂,KOH为催化剂,十六烷基三甲基溴化铵(CTMAB)为相转移催化剂合成盐酸氟桂利嗪。结果:最佳条件为:n(肉桂基哌嗪)∶n(二氟苯基溴甲烷)∶n(KOH)=1∶1∶1.3,2g十六烷基三甲基溴化铵/1mol二氟苯基溴甲烷,反应时间4h,反应温度42℃,收率可达92.7%。结论:相转移催化剂十六烷基三甲基溴化铵(CTMAB)对合成盐酸氟桂利嗪的产品收率和质量均有较大的提高。 |
| 关 键 词： | 盐酸氟桂利嗪 相转移催化剂 合成 |
| 文章编号： | 1672-7606(2006)01-0024-02 |
| 收稿时间： | 2006-02-14 |
| 修稿时间： | 2006年2月14日 |
Application of phase transfer catalysis in the production of Flunarizine Hydrochloride |
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| GONG Zi-dong,MENG Xiang-tao,ZHANG Xiang-ju,LI Xiao-yan.Application of phase transfer catalysis in the production of Flunarizine Hydrochloride[J].Journal of Henan University,2006,25(2):24-25. | |
| Authors: | GONG Zi-dong MENG Xiang-tao ZHANG Xiang-ju LI Xiao-yan |
| Institution: | 1. Henan Pharmaceutical School, Kaifeng475001, Henan , China; 2. Henan Art School, Zhengzhou450000, Henan, China; 3. Kaifeng Longhai Hospital, Kaifeng 475003, Henan, China |
| Abstract: | Objective: To study the influence of CTMAB to the synthesis of Flunarizine Hydrochloride.Methods: Flunarizine Hydrochloride was synthesized by using C_(13)H_(18)N_(2)and C_(13)H_(11)F_(2)Br as material,KOH as catalyst,and CTMAB as phase transfer catalyst.Results: The optimum condition was:n(C_(13)H_(18)N_(2))∶n(C_(13)H_(11)F_(2)Br) ∶ n(KOH) = 1∶1∶1.3,2g MTBAB / 1molC_(13)H_(11)F_(2)Br,reaction time 4h and tempreture 42℃.The yield reached to 92.7%.Conclusion: Phase transfer catalysis CTMAB can increase significantly the yield and quality of the production of synthetical Flunarizine Hydrochloride. |
| Keywords: | phase transfer catalyst Flunarizine Hydrochloride |
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