| 热休克蛋白10在大肠癌的表达及其临床病理意义 |
| |
| 引用本文： | Junhui Chen,Liming Chen,Shaobin Wang,Jiexiong Huang,Qiancheng Qu,Liyan Xu.热休克蛋白10在大肠癌的表达及其临床病理意义[J].中德临床肿瘤学杂志,2007,6(4):334-338. |
| |
| 作者姓名： | Junhui Chen Liming Chen Shaobin Wang Jiexiong Huang Qiancheng Qu Liyan Xu |
| |
| 作者单位： | [1]Department of Oncology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041,China [2]Department of Pathology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China [3]Department of Pathology, Medical College of Shantou University, Shantou 515041, China |
| |
| 摘 要： | Objective： To investigate the expression of heat shock protein 10 （HSPIO） during genesis and development of large bowel carcinoma and discuss the clinical significance about its expression. Methods： The expression of HSPIO was observed in specimens from normal colonic mucosa （NC）, colorectal adenomas （CA） and colorectal adenocarcinomas （CAC） by immunohistochemistry EnVisionTM. Its correlations to clinicopathologic features, as well as to postoperative survival time of large bowel carcinoma patients were analyzed. Results： The expression of HSPIO was common in normal colonic mucosa, colorectal adenomas and adenocarcinomas and more intensive in colorectal adenomas and adenocarcinomas than that in normal colonic mucosa （P 〈 0.001）. The positive expression of HSPIO had no correlation to clinicopathologic features, including age, gender, primary tumor, infiltrating of regional lymph node, metastasis, clinical stage and histopathology of large bowel carcinoma patients, as well as to their postoperative survival time. Conclusion： HSPIO was overexpressed in the early stage of colorectal adenocarcinoma suggesting that it could serve as an index for early diagnosis of large bowl carcinoma. The positive expression of HSPIO had no correlation to clinicopathologic features or postoperative survival time of large bowel carcinoma patients.
|
| 关 键 词： | 热休克蛋白10 大肠癌 基因表达 临床病理 |
| 收稿时间： | 12 February 2007 |
| 修稿时间： | 2007-02-12 |
Clinical significance of heat shock protein 10 in large bowel carcinoma |
| |
| Junhui?Chen,Liming?Chen,Shaobin?Wang,Jiexiong?Huang,Qiancheng?Qiu,Liyan?Xu.Clinical significance of heat shock protein 10 in large bowel carcinoma[J].The Chinese-German Journal of Clinical Oncology,2007,6(4):334-338. |
| |
| Authors: | Junhui Chen Liming Chen Shaobin Wang Jiexiong Huang Qiancheng Qiu Liyan Xu |
| |
| Institution: | Department of Oncology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China ; Department of Pathology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China ; Department of Pathology, Medical College of Shantou University, Shantou 515041, China |
| |
| Abstract: | Objective: To investigate the expression of heat shock protein 10 (HSP10) during genesis and development of large bowel carcinoma and discuss the clinical significance about its expression. Methods: The expression of HSP10 was observed in specimens from normal colonic mucosa (NC), colorectal adenomas (CA) and colorectal adenocarcinomas (CAC)by immunohistochemistry EnVisionTM. Its correlations to clinicopathologic features, as well as to postoperative survival time of large bowel carcinoma patients were analyzed. Results: The expression of HSP10 was common in normal colonic mucosa,colorectal adenomas and adenocarcinomas and more intensive in colorectal adenomas and adenocarcinomas than that in normal colonic mucosa (P ＜ 0.001). The positive expression of HSP10 had no correlation to clinicopathologic features, including age, gender, primary tumor, infiltrating of regional lymph node, metastasis, clinical stage and histopathology of large bowel carcinoma patients, as well as to their postoperative survival time. Conclusion: HSP10 was overexpressed in the early stage of colorectal adenocarcinoma suggesting that it could serve as an index for early diagnosis of large bowl carcinoma. The positive expression of HSP10 had no correlation to clinicopathologic features or postoperative survival time of large bowel carcinoma patients. |
| |
| Keywords: | heat shock protein 10 colorectal neoplasm immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ |
|
