BNP、TnT水平对急性肺栓塞病情评估的临床意义

目的探讨脑钠肽(BNP)、肌钙蛋白T(Tn T)对急性肺栓塞(APE)病情评估的临床意义。方法选取2010年12月至2014年2月间首都医科大学大兴教学医院急诊科APE患者74例,男性42例,女性32例,年龄19~84岁,平均年龄(55.1±16.6)岁。根据BNP和Tn T水平分为3组,BNP+Tn T均阴性为A组40例,单纯BNP阳性为B组24例,BNP+Tn T均阳性为C组10例。测定所有患者BNP、Tn T水平;记录患者入院后症状缓解时间及住院总时间。结果与A组比较,B组发生晕厥的比例升高(2.5%vs.16.7%),与B组比较,C组发生晕厥的比例升高(16.7%vs.50.0%),差异具有统计学意义(P均0.05)。与B组比较,C组BNP水平升高,差异具有统计学意义(P0.05)。Tn T与住院总时间呈正相关(r=0.537,P0.05)。结论 BNP、TNT均是APE患者病情评估的重要指标,两者均升高的APE患者应积极处理。

Clinical significance of brain natriuretic peptide and troponin T levels in reviewing severity of acute pulmonary embolism

Objective To discuss the clinical significance of brain natriuretic peptide （BNP） and troponin T （TnT） levels in reviewing severity of acute pulmonary embolism （APE）.Methods APE patients （n=74, male 42 and female 32） aged from 19 to 84 （average age=55.1±16.6） were chosen from Dec. 2010 to Feb. 2014, and divided into 3 groups according to the levels of BNP and TnT, including group A （negative BNP＋TnT,n=40）, group B （negative BNP only,n=24） and group C （positive BNP＋TnT,n=10）. The levels of BNP and TnT were detected in all patients, and symptom relieving time after admission and the total hospitalization time were recorded.Results Compared with group A, the percentage of faint patients increased in group B （2.5%vs. 16.7%）, and compared with group B, that increased in group C （16.7%vs. 50.0%, allP〈0.05）. Compared with group B, BNP level increased in group C （P〈0.05）. TnT was positively correlated to the total hospitalization time （r=0.537,P〈0.05）.Conclusion BNP and TnT are important indexes for reviewing severity of APE. If patients have both increased BNP and TnT, they should be treated actively.