不同年龄重症冠心病患者高敏C反应蛋白、应激性血糖及糖化血红蛋白的比较

目的探讨不同年龄重症冠状动脉粥样硬化性心脏病(冠心病)患者高敏C反应蛋白(hsCRP)、应激性血糖和糖化血红蛋白的变化。方法入选2012年1月到2013年1月在唐山市工人医院ICU及CCU住院的重症冠心病患者514例,其中男性284例,女性230例,年龄24~91岁,平均年龄(67.65±12.68)岁。根据患者年龄分为4组:A组(60岁,n=134);B组(60~69岁,n=132);C组(70~80岁,n=154);D组(≥80岁,n=94)。检测各组患者血清hs-CRP、全血血糖和全血糖化血红蛋白水平。结果与A组[(7.10±22.67)mg/L]比较,B组[(15.56±35.23)mg/L]、C组[(19.57±37.97)mg/L]、D组[(29.29±44.43)mg/L]hs-CRP呈逐渐增高趋势,差异具有统计学意义(P0.05)。与A组[(8.67±4.13)mmol/L]比较,B组[(9.26±5.93)mmol/L]、C组[(10.84±6.05)mmol/L]血糖呈逐渐增高趋势,差异具有统计学意义(P0.05)。C组与D组血糖比较无统计学差异(P0.05)。各组间糖化血红蛋白比较均无统计学差异(P0.05)。结论不同年龄重症冠心病患者入院时hs-CRP和应激性血糖随着年龄的增长而增加,而糖化血红蛋白无明显变化。

Comparison in changes of high-sensitivity C-reactive protein,stress blood glucose and glycated hemoglobin in patients with severe coronary heart disease in different ages

Objective To investigate the changes of high-sensitivity C-reactive protein （hs-CRP）, stress blood glucose and glycated hemoglobin in patients with severe coronary heart disease （CHD） in different ages. Methods The patients （n=514） were chosen （male 284 and female 230） aged from 24 to 91 （average age=67.65±12.68） from Jan. 2012 to Jan. 2013. All patients were divided, according to their age, into group A （age〈60, n=134）, group B （aged from 60 to 69, n=132）, group C （aged from 70 to 80, n=154） and group D （age≥80, n=94）. The levels of serum hs-CRP, stress blood glucose and glycated hemoglobin were detected in all groups. Results The level of hs-CRP increased gradually in group B [（15.56±35.23） mg/L], group C [（19.57±37.97） mg/L] and group D [（29.29±44.43） mg/L] compared with group A [（7.10±22.67） mg/L, P〈0.05]. The level of blood glucose increased gradually in group B [（9.26±5.93） mmol/L] and group C [（10.84±6.05） mmol/L] compared with group A [（8.67±4.13） mmol/L, P〈0.05]. The comparison in blood glucose between group C and group D had no statistical difference （P〉0.05）, and comparison in glycated hemoglobin among all groups had no statistical difference （P〉0.05）. Conclusion The levels of hs-CRP and stress blood glucose increase as aging and level of glycated hemoglobin has no significant change in patients with severe CHD in different ages.