复杂疾病病因研究中基因问交互作用分析:基于基因型传递不平衡的多因子降维法

介绍复杂疾病病因研究中分析基因-基因交互作用的一种新方法：基于基因型传递不平衡的多因子降维法（MDR-PDT）。文中简述MDR-PDT的基本原理、步骤及特点，并结合研究实例说明其应用过程。MDR-PDT是原始MDR的扩展，可用于多种结构类型的核心家系资料分析基因-基因交互作用。结论MDR-PDT具有非参数、无需遗传模式的特点，并能充分利用家系中多个家庭成员的信息，在复杂疾病病因研究中分析基因-基因交互作用具有良好的效能。

Identification of gene-gene interactions related to the etiology of complex disease: a multifactor dimensionality reduction-genotype pedigree disequilibrium test

To introduce the application of a multifactor dimensionality reduction-genotype pedigree disequilibrium test (MDR-PDT) for detecting gene-gene interactions in the etiology of complex disease. A brief overview on the basic theory, implementing steps and features of MDR-PDT were described, and a practical research case was demonstrated to application of MDR-PDT in nuclear family studies. The MDR-PDT approach was the extension or development of conventional MDR method which could be used for detecting gene-gene interactions in families of diverse structure. CONCLUSION: MDR-PDT was a new nonparametric and model-free method which might use additional family members in the nuclear families and had a good power to identify gene-geneinteractions.