结核分枝杆菌对常见的一线和二线药物耐药机制的研究进展

结核分枝杆菌是引起结核病(TB)的病原体,可侵犯全身各种器官,病死率较高。而结核病的耐药性已成为了一个日益严重的公共卫生问题,严重威胁着结核病的防治。治疗结核病主要的一线和二线药物包括异烟肼、利福平、吡嗪酰胺、链霉素和喹诺酮类等,深入了解这些抗结核药物的耐药机制可进一步指导抗结核新药的研制。

Advances in the mechanism of drug resistance to common first-line and second-line drugs in Mycobacterium tuberculosis

Mycobacterium tuberculosis is a pathogen that causes tuberculosis (TB), which can invade various organs of the human body and has a high mortality. The drug resistance of tuberculosis has become an increasingly serious public health problem, which is a serious threat to the prevention and treatment of tuberculosis. The main first-line and second-line anti-tuberculosis drugs include isoniazid, rifampicin, pyrazinamide, streptomycin and quinolones, and in-depth understanding of the mechanisms of resistance to these anti-tuberculosis drugs can further guide the research and development of new drugs to fight tuberculosis.