疏肝宁胃汤联合奥美拉唑对慢性浅表性胃炎患者血清COX-2、Gas水平的影响

摘要]目的 探究疏肝宁胃汤联合奥美拉唑对慢性浅表性胃炎（CSG）患者血清环氧化酶-2（COX-2）及胃泌素（Gas）水平的影响。方法 纳入88例2018年9月-2020年8月我院收治的CSG患者，依据随机数字表法分为研究组（n=44）及对照组（n=44）。对照组服用奥美拉唑，研究组在上述基础上联合疏肝宁胃汤，两组均治疗1个月。对比两组临床疗效、中医证候积分、血清COX-2、Gas水平、炎症因子白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）]水平及不良反应。结果 治疗总有效率研究组为95.45%（42/44），高于对照组75.00%（33/44），有统计学差异（P＜0.05）；研究组治疗后胃脘胀痛积分（1.02±0.21）分]、嗳气频繁积分（1.05±0.26）分]、嘈杂泛酸积分（0.98±0.10）分]、胆汁反流积分（0.89±0.08）分]均低于对照组（2.53±0.36）分、（2.49±0.30）分、（1.98±0.13）分、（1.65±0.11）分]，有统计学差异（P＜0.05）；研究组治疗后COX-2水平（5.43±0.76）IU/L]、Gas水平（18.24±3.16）ng/L]均低于对照组（9.87±1.05）IU/L、（27.20±2.87）ng/L]，有统计学差异（P＜0.05）；研究组治疗后IL-6水平（17.31±4.62）ng/L]、TNF-α水平（19.51±4.19）ng/L]低于对照组（20.52±4.81）ng/L、（25.57±5.52）ng/L]，有统计学差异（P＜0.05）；不良反应研究组为4.55%（2/44），低于对照组的18.18%（8/44），有统计学差异（P＜0.05）。结论 疏肝宁胃汤联合奥美拉唑在CSG患者治疗中有助于改善各临床症状，抑制炎症反应，降低COX-2、Gas水平，不良反应少，疗效确切，安全性高。

Effect of gastric soup combined with omeprazole on serum COX-2 and Gas levels in patients with chronic superficial gastritis

Abstract] Objective To explore the effect of gastric soup combined with omeprazole on serum cyclooxygenase-2 (COX-2) and gastrin (Gas) levels in patients with chronic superficial gastritis (CSG).Methods 88 CSG patients admitted to our hospital from September 2018 to August 2020 were divided into study group (n=44) and control group (n=44) according to random numbers method.The control group was on omeprazole, the study group combined with gastric soup on the above basis, and both groups were treated for 1 month.The clinical efficacy, TCM syndrome score, serum COX-2, Gas levels, inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor- (TNF-)] levels and adverse effects were compared.Results The total response rate study group was 95.45% (42 / 44), Higher than the control group, 75.00% (33 / 44), Statistically different (P <0.05); The points (1.02 ± 0.21)], frequent belching (1.05 ± 0.26)], noisy pantothenic acid (0.98 ± 0.10)], bile reflux (0.89 ± 0.08)] were lower than the control group (2.53 ± 0.36), (2.49 ± 0.30), (1.98 ± 0.13), (1.65 ± 0.11)], Statistically different (P <0.05); COX-2 (5.43 ± 0.76) IU / L] and Gas (18.24 ± 3.16) ng/L] were lower than the control group (9.87 ± 1.05) IU / L, (27.20 ± 2.87) ng/L], Statistically different (P <0.05); IL-6 levels (17.31 ± 4.62) ng/L], TNF-levels (19.51 ± 4.19) ng/L] were lower than the control group (20.52 ± 4.81) ng/L, (25.57 ± 5.52) ng/L], Statistically different (P <0.05); The adverse R study group was 4.55% (2 / 44), Less than 18.18% (8 / 44) of the control group, Statistical difference (P <0.05).Conclusion Combined with omeprazole can help to improve various clinical symptoms, inhibit inflammatory response, reduce COX-2 and Gas levels, with few adverse effects, definite efficacy and high safety.