虚拟现实技术在阿尔茨海默病患者认知功能评估中的应用进展

随着人口老龄化，阿尔茨海默病（Alzheimer''s disease，AD）等神经退行性疾病的发病率逐年攀升。认知功能损害和神经精神行为异常是AD的典型症状。认知功能损害主要表现为记忆力、逻辑思维能力、语言能力、执行能力和注意力下降；神经精神行为症状主要包括抑郁、欣快、淡漠等。以上症状可严重影响患者日常生活能力和生活质量。目前AD是无法治愈的，因此早发现、早诊断、早治疗对延缓患者病程的进展、提高患者生活质量、减少照料者和社会的负担有重要意义。目前针对AD的认知评估主要通过神经心理量表测试，但该方法有许多弊端。本文重点介绍基于虚拟现实技术（virtual reality，VR）认知评估的最新进展，旨在为家庭或临床环境提供更可靠的诊断。

Application progress of virtual reality in cognitive function assessment of Alzheimer's disease patients

With the aging of the population, the incidence of neurodegenerative diseases such as Alzheimer''s disease (AD) is rising year by year. Cognitive impairment and neuropsychiatric symptoms are typical manifestations of AD. Cognitive impairment is mainly manifested in the decline of memory, logical ability, language ability, executive ability and attention. Neuropsychiatric symptoms mainly include depression, euphoria, apathy and so on. The above symptoms can affect the patient''s daily living ability and quality of life. At present, there is no cure for AD, so early detection, diagnosis and treatment are of great significance for delaying the progression of the disease, improving the quality of life of patients, and reducing the burden on caregivers and society. At present, the cognitive assessment of AD is mainly based on neuropsychological scale test, but this method still has many disadvantages. This review focuses on the latest advances in cognitive assessment based on virtual reality (VR), which aims to provide more reliable diagnosis for home or clinical settings.