心率变异性与高血压病动脉硬化和早期肾脏损害的相关性研究

目的 探讨心率变异性与高血压病动脉硬化和早期肾损害的相关性。 方法 对健康体检中筛选已确诊原发性高血压病164 例,进行心率变异性(HRV-SDNN)、尿微量白蛋白和臂踝脉搏波传导速度(baPWV)以及血压、BMI和血生化检查检测,并与200例健康受试者(正常对照组)进行对比分析。 结果 (1)两组在脉压差、体重指数(BMI)、低密度胆固醇(LDL)、甘油三酯(TG)、高密度脂蛋白(HDL)、血糖、血尿酸、尿微量白蛋白、baPWV和SDNN方面的比较,差异有统计学意义(均P＜0.05)。(2)SDNN与baPWV两者具有明显相关性(r=-0.72,P＜0.01)。(3)SDNN与尿微量白蛋白两者具有显著相关性(r=-0.81,P＜0.01)。 结论 心率变异性降低是高血压病动脉粥样硬化和早期肾功能损害的危险因素。通过心率变异性的分析, 对评估和预测血管病变和靶器官损害均有重要的指导意义。

Correlation of heart rate variability with arteriosclerosis and early kidney impairment in hypertension

Objective To explore the relationship of heart rate variability with arteriosclerosis and early kidney impairment in hypertension. Methods One hundred and sixty-four patients diagnosed with primary hypertension during physical examinations served as the hypertension group, and 200 healthy adults were considered as the normal control group. The heart rate variability (HRV), urinary albumin, brachial-ankle pulse wave velocity (baPWV), blood pressure, budy mass index (BMI) and blood biochemical indicators were detected and compared between the two groups. Results There were statistically significant differences in pulse pressure, BMI, LDL, TG, HDL, GLU, UA, urinary albumin, baPWV and standard deviation of normal-to-normal intervals (SDNN) between the hypertension group and the normal control group (all P<0.05). There was a significant correlation between SDNN and baPWV (r=-0.72, P<0.01) as well as between SDNN and urinary albumin (r=-0.81, P<0.01). Conclusions The reduction of HRV is the risk factor for arteriosclerosis and early kidney impairment in hypertension. HRV assessment is of great value in evaluation and forecast of vascular lesion and target organ damage.