窒息对新生儿多种内分泌激素的影响

目的：评价窒息缺氧对新生儿瘦素，胰岛素，生长激素，甲状腺素，糖皮质激素及体重的影响。方法：应用放射免疫法测定23例（窒息组）中，重度窒息缺氧新生儿及无窒息12例（对照组）新生儿静脉血血浆瘦素，胰岛素，生长激素，甲状腺素，皮质醇水平。结果：窒息组新生儿出生后5d体重增长下降（P＜0．05），出生后24－48h血浆生长激素，甲状腺素水平明显低于对照组（分别P＜0．01，P＜0．05）；而瘦素，皮质醇，胰岛素明显高于对照组（分别为P＜0．05，P＜0．01，P＜0．05）。出生后第5d上述5种内分泌激素水平才接受正常。结论：窒息缺氧影响新生儿多种内分泌激素变化，不利于生长，发育，提出可能纠正的方法。

Effect of Neonatal Asphyxia on 5 Kinds of Endocrine Hormones

Objective: To evaluate the effect of neonatal asphyxia on leptin, insulin, growth hormone, thyroxin, corticosteoid and body weight. Methods: Twenty three newborns with moderate severe asphyxia were studied and 12 newborns without asphyxia newborns served as control. Plasma leptin, insulin, growth hormone, thyroxin, corticosteoid were measured by using radioimmunoassay.Results: Moderate severe asphyxia resulted in a significant decrease of plasma growth hormone, thyroxin ( P <0.01 , P <0.05 ), and an increase of leptin, corticosteoid, insulin 24-48 h after birth ( P < 0.05 , P < 0.01 , P < 0.05 respectively). The increase of body weight at the 5th day after birth was decreased ( P < 0.05 ). At the 5th day after birth, the above hormones were close to the normal. Conclusion: The endocrine changes of the asphyxia newborns interfere with the growth and development.