| 复方三七滴丸对急性血瘀证大鼠血液流变学和家兔血小板聚集及血栓形成的影响 |
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| 引用本文： | 孔燕,潘文军,黄永军,杨静玉,陈永洪,晏永新,张小娟,吴春福.复方三七滴丸对急性血瘀证大鼠血液流变学和家兔血小板聚集及血栓形成的影响[J].中国现代中药,2006,8(1):8-10. |
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| 作者姓名： | 孔燕 潘文军 黄永军 杨静玉 陈永洪 晏永新 张小娟 吴春福 |
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| 作者单位： | 1. 沈阳药科大学药理系,辽宁,沈阳,110016
2. 江西本草天工科技有限公司,江西,南昌,330006 |
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| 摘 要： | 目的：研究复方三七滴丸对血瘀证大鼠血液流变学、血小板聚集以及体外血栓形成的影响。方法：运用皮下注射大剂量肾上腺素加冰水冷浴造大鼠血瘀模型，观察复方三七滴丸对大鼠血瘀模型血液流变学的影响：采用家兔血小板聚集试验和体外血栓形成试验研究复方三七滴丸抗血栓形成的作用。结果：复方三七滴丸能使血瘀证大鼠的血液流变学主要指标明显改善，并抑制家兔血小板聚集、家兔体外血栓形成。结论：复方三七滴丸能有效改善急性血瘀证大鼠血液流变学异常，具有抗血小板聚集和杭血栓形成的作用。
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| 关 键 词： | 复方三七滴丸 急性血瘀证模型 血液流变学 血小板聚集 血栓形成 |
| 收稿时间： | 2005-11-28 |
| 修稿时间： | 2005年11月28 |
Effects of Fufang Sanqi Pills on Hemorheological Parameters, Platelet Aggregation and Thrombus Fromation in Experimental Animals |
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| Kong Yan,Pan Wenjun,Huang Yongjun,Yang Jingyu,Chen Yonghong,Yan Yongxin,Zhang Xiaojuan and Wu Chunfu.Effects of Fufang Sanqi Pills on Hemorheological Parameters, Platelet Aggregation and Thrombus Fromation in Experimental Animals[J].Modern Chinese Medicine,2006,8(1):8-10. |
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| Authors: | Kong Yan Pan Wenjun Huang Yongjun Yang Jingyu Chen Yonghong Yan Yongxin Zhang Xiaojuan and Wu Chunfu |
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| Affiliation: | Department of Pharmacology, Shenyang Pharmaceutical Unviersity, Shenyang Liaoning 110016, China;Department of Pharmacology, Shenyang Pharmaceutical Unviersity, Shenyang Liaoning 110016, China;Department of Pharmacology, Shenyang Pharmaceutical Unviersity, Shenyang Liaoning 110016, China;Department of Pharmacology, Shenyang Pharmaceutical Unviersity, Shenyang Liaoning 110016, China;Jiangxi Bencao Tiangong Science and Technology Company, Nanchang Jiangxi 330006, China;Jiangxi Bencao Tiangong Science and Technology Company, Nanchang Jiangxi 330006, China;Jiangxi Bencao Tiangong Science and Technology Company, Nanchang Jiangxi 330006, China;Department of Pharmacology, Shenyang Pharmaceutical Unviersity, Shenyang Liaoning 110016, China |
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| Abstract: | Objective: To investigate the effects of Fufang Sanqi Pills on hemorheological parameters, plate- let aggregation and thrombus formation in vitro. Methods: The acute blood stasis model in rats were established with subcutaneous injection of adrenaline hydrochloride and being socked in ice-water. Results: The Fufang Sanqi Pills could not only significantly reduce the hemorheological parameters in acute blood stasis rat models but also remarkedly inhibit the platelet aggregation in rabbit and thrombus formation in vitro. Conclusion: Fufang Sanqi Pills could obviously ameliorate the hemorheological parameters,inhibit platelet aggregation and thrombus formation. |
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| Keywords: | Fufang Sanqi Pills acute blood stasis model hemorheology platelet aggregation thrombus formation |
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