| 海龙体外抗肿瘤活性研究 |
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| 引用本文： | 李士敏,吴筱丹,曾苏,栾连军,邵青.海龙体外抗肿瘤活性研究[J].中国中药杂志,2001,26(3):198-200. |
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| 作者姓名： | 李士敏 吴筱丹 曾苏 栾连军 邵青 |
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| 作者单位： | 浙江大学 药物制剂研究所，浙江 杭州 310031 |
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| 基金项目： | 浙江省自然科学基金课题(395131) |
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| 摘 要： | 目的 :筛选不同品种海龙的体外抗肿瘤活性部位。方法 :采用MTT法观察海龙的各种提取物对多种人癌细胞株生长的影响。结果 :尖海龙的 95%乙醇提取物对KB细胞的生长具有抑制作用 ,并呈量效关系 ;粗吻海龙的脂溶性非皂化物具有不同程度的抑制人癌细胞株KB ,Hela ,Bcap37,K562 ,PAA细胞的作用 ,并有明显的量效关系 ;拟海龙的各提取物未见有明显的抑制肿瘤细胞生长的作用。结论 :海龙是一种有开发前景的抗肿瘤中药。
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| 关 键 词： | 拟海龙 尖海龙 粗吻海龙 体外抗肿瘤 MTT法 |
| 文章编号： | 1001-5302(20001)03-0198-03 |
| 收稿时间： | 1999/10/8 0:00:00 |
| 修稿时间： | 1999年10月8日 |
Study on Anticancer Activity of Syngnathus in Vitro |
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| LI Shi-min;WU Xiao-dan;ZENG Su;LUAN Lian-jun;SHAO Qing.Study on Anticancer Activity of Syngnathus in Vitro[J].China Journal of Chinese Materia Medica,2001,26(3):198-200. |
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| Authors: | LI Shi-min;WU Xiao-dan;ZENG Su;LUAN Lian-jun;SHAO Qing |
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| Institution: | School of Pharmacy, Zhejiang University, Hangzhou 310031, Zhejiang, China. |
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| Abstract: | Objective: To study the anticancer activity of Syngnathus in vitro. Method: Observing the influence of different extracts from Syngnathus on growth of different cancer cell strains by MTT method. Result: It has been found out that the fat-soluble nonsaponified extract from Temminck et Schlegel and the alcoholic extract from Syngnathus acus have cytotoxic activities.The nonsaponified extract from Temminck et Schlegel can inhibit the grouth of cancer cell strains KB,Hela,PAA,K562,and Bcap37,and the alcoholic extract from Syngnathus acus can inhibit the growth of cancer cell strin KB,But Bloch shows no apparent anticancer activity. Conclusion: Syngnathus has promising prospects as an anticancer Chinese medicine. |
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| Keywords: | Syngnathus acus Syngnathoides biaculeatus Trachyrhamphus serratus anticancer activity in vitro MTT method |
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