免疫应答类型的重新分类

过渡性免疫应答由原属固有免疫应答的原始B1细胞、γδT细胞和NKT细胞所组成.其中原始B1细胞承担过渡性免疫应答的体液免疫,γδT细胞和NKT细胞承担过渡性免疫应答的细胞免疫,主要识别和排除TI抗原.固有免疫应答的细胞包括吞噬细胞、树突状细胞、NK细胞等,体液免疫组包括补体、急性期蛋白、溶菌酶等,其主要作用是非特异性地清除或递呈抗原.适应性免疫应答的细胞由B2细胞和αβT细胞组成,B2细胞承担适应性体液免疫应答,αβT细胞承担适应性细胞免疫应答,主要识别和排除胸腺依赖性抗原(TD).免疫应答分为3种类型是对免疫系统进化的客观阐述,符合物种进化的基本规律,准确反映了免疫功能的发生和发展,对完善免疫学基础理论以及指导临床免疫学研究具有重要的意义.

Types of immune response have been renewed classification

The intermediate immune response involves cells such as primitive B1 cells, γδT cells, and NKTcells that all belong to innate immune response in the ever existing two immune responses theory. In this newly-proposed theory, primitive B1 cells are assumed to play a role in humoral immunity, whereas γδT cells andNKT cells are implicated in the cellular mediated immunity, mainly for recognizing and eliminating thymic inde-pendent antigens. The innate immune response involves cells such as phagocytes, dendritic cells, natural killercells etc. , and those humoral immune components such as complements, acute phase proteins, lysozymes, etc.The major role of these components is to non-specifically eliminate or present antigens. The adaptive immuneresponse involves B2 cells and αβT cells. The former is assumed to be active in humoral immunity, while thelatter is assumed to participate in cellular mediated immunity and to recognize and eliminate thymic dependentantigens. The hypothesis about three types of immune responses is more objective in elucidating the basic rulesof the species evolution and development of immune system. It is of highly importance to improve basic theory ofimmunology, and to promote researches on clinical immunology.