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糖调节受损和2型糖尿病患者血浆nesfatin-1水平的变化
引用本文:苏静,叶菲,李志勇,杨刚毅,朱伟,李伶,瞿文娟,吴丹冬,张志红. 糖调节受损和2型糖尿病患者血浆nesfatin-1水平的变化[J]. 中华内分泌代谢杂志, 2012, 28(1). DOI: 10.3760/cma.j.issn.1000-6699.2012.01.009
作者姓名:苏静  叶菲  李志勇  杨刚毅  朱伟  李伶  瞿文娟  吴丹冬  张志红
作者单位:1. 400010重庆医科大学附属第二医院内分泌科
2. 重庆医科大学附属永川医院
3. 重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室
摘    要:采用酶联免疫法测定了初诊2型糖尿病患者、糖调节受损(IGR)患者、正常糖耐量(NGT)者血浆nesfatin-1水平.结果显示,2型糖尿病和IGR组血浆nesfatin-1水平明显高于NGT组[(1.91±0.79和1.80±0.80对1.41±0.58)μg/L,P<0.01].血浆nesfatin-1水平与体重指数(BMI)、空腹血糖、空腹胰岛素、HbA1C、稳态模型评估的胰岛素抵抗指数(HOMA-IR)呈明显正相关(P<0.05或P<O.01).多元回归分析结果表明HOMA-IR和BMI分别是影响血浆nesfatin-1水平的独立相关因素(均P<0.01).提示血浆nesfatin-1可能参与了胰岛素抵抗和2型糖尿病的发生和发展.

关 键 词:Nesfatin-1  胰岛素抵抗  糖调节受损  糖尿病,2型

Changes of plasma nesfatin-1 levels in patients with impaired glucose regulation and type 2 diabetes mellitus
SU Jing,YE Fei,LI Zhi-yong,YANG Gang-yi,ZHU Wei,LI Ling,QU Wen-juan,WU Dan-dong,ZHANG Zhi-hong. Changes of plasma nesfatin-1 levels in patients with impaired glucose regulation and type 2 diabetes mellitus[J]. Chinese Journal of Endocrinology and Metabolism, 2012, 28(1). DOI: 10.3760/cma.j.issn.1000-6699.2012.01.009
Authors:SU Jing  YE Fei  LI Zhi-yong  YANG Gang-yi  ZHU Wei  LI Ling  QU Wen-juan  WU Dan-dong  ZHANG Zhi-hong
Abstract:Plasma nesfatin-1 levels were assayed by ELISA in patients with impaired glucose regulation (IGR),type 2 diabetes mellitus( T2DM ),and healthy subjects with normal glucose tolerance( control group).The results showed that plasma nesfatin-1 levels in IGR and T2DM groups were significantly higher than that in control group [ ( 1.91 ±0.79 and 1.80±0.80 vs 1.41 ±0.58) μg/L,P<0.01 ].Plasma nesfatin-1 levels were positively correlated with body mass index(BMI),HbA1c,waist hip ratio,fasting plasma glucose,fasting insulin,and homoestasis model assessment insulin resistant index( HOMA-IR,P<0.05 or P<0.01 ).Multiple regression analysis showed that BMI and HOMA-IR were independent related factors in influencing plasma nesfatin-1 levels (both P<0.01 ).These results suggest that nesfatin-1 may partially contribute to the pathogenesis of insulin resistance and T2DM.
Keywords:Nesfatin-1  Insulin resistance  Impaired glucose regulation  Diabetes mellitus,type 2
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