三叉神经痛MRI序列研究及诊断价值

目的 探讨MR序列对导致三叉神经痛病变的显示能力及诊断价值.方法 回顾性分析60例三叉神经痛患者临床及MRI资料,与临床手术对照,比较不同序列MRI显示病变能力.所有患者均行常规头部MR平扫,其中9例行增强扫描,49例行桥小脑角区高分辨3D-TOF和3D-快速SE(TSE)序列扫描.利用x2检验分析3D-TOF和3D-TSE两序列的敏感度、特异度和准确度.结果 MR常规平扫及增强扫描显示6例桥小脑区肿瘤、3例三叉神经根及其周围脑膜炎,以及脑干多发硬化斑块及梗死各1例.49例为神经血管压迫所致,与手术对照3D-TOF和3D-TSE序列显示血管压迫的敏感度、特异度、准确度分别为95.3％ (41/43)、66.7％ (4/6)、91.8％ (45/49)和95.6％ (43/45)、50.0％ (2/4)、91.8％ (45/49),两者差异无统计学意义(x2值分别为0.13、0.19、0.17,P值均＞0.5).结论MRI对显示和诊断三叉神经痛病因具有重要意义.MR全脑常规扫描可以显示或排除肿瘤、炎症等病变.桥小脑角区3D-TOF和3D-TSE扫描可以敏感和准确地显示和明确神经、血管的关系.

The study and diagnostic value of MRI sequences in patients with trigeminal neuralgia

Objective To investigate the capacity and diagnostic value of various MRI seguences in patients with trigeminal neuralgia.Methods MR images of 60 patients with trigeminal neuralgia were analyzed retrospectively.The sensitivity,specificity and diagnostic value of various MRI sequences were evaluated comparing with clinical data and operation results.All patients were scanned with conventional sequences including SE-T1WI,T2WI,FLAIR of head.Among them,9 cases were injected with contrast agent,49 cases were scanned with 3D-TOF and 3D-TSE sequences on cerebellopontine angle additinally.The sensitivity,specificity and accuracy of the 3D-TOF and 3D-TSE sequences were analyzed by using the x2 test.Results Six cases with tumor,3 cases with radiculitis and meningitis,1 case with multiple sclerosis and 1 case with pons infarction were diagnosed by conventional MR sequences.MRI of 49 cases with 3D-TOF and 3D-TSE showed neurovascular compress proved by operation.The sensitivity,specificity and accuracy of 3D-TOF and 3D-TSE were 95.3％ (41/43)vs.95.6％ (43/45),66.7％ (4/6)vs.50.0％(2/4) and 91.8％ (45/49)vs.91.8％ (45/49),and no significantly difference was found between the two sequences (x2 =0.13,0.19 and 0.17,P ＞0.5).Conclusions MRI plays an important role in displaying the causes and diagnosis of trigeminal neuralgia.The conventional head MR sequences should be recommended for diagnosis of secondary TN caused by tumor and inflammation et al,and further 3D-TOF and 3D-TSE with high sensitivity and accuracy should be applied in patients with primary TN to display the neurovascular relationship.