CD64、CRP、IL-6在儿科感染性疾病中的诊断价值分析

目的探讨中性粒细胞表面标志物CD64、CRP、IL-6在儿科感染性疾病中的应用价值。方法将2007年10月～2011年10月儿科病房（包括NICU住院）住院患儿116例,分为重症感染组（49例）;一般感染组（36例）;非感染组（31例）。3组进行CD64、CRP、IL-6水平测定和比较。结果重症感染组CD64为（6262.24±3776.43）分子数/细胞,感染组为（3727.24±1276.32）分子数/细胞,非感染组为（2176.19±946.32）分子数/细胞,重症感染组CD64水平明显高于其他两组,3组间CD64值差异有极显著意义（P〈0.01）。CD64诊断感染的最佳临界值为2587分子数/细胞,其诊断重症感染的敏感度为89.21%,特异度为78.35%;对所有感染的诊断敏感度为67.51%,特异度为82.45%。结论细菌感染时CD64水平明显升高,全身性细菌感染时升高尤为明显,与CRP、IL-6相比诊断优越性更明显,特别对重症感染患儿诊断更有价值,可以作为早期诊断儿科感染性疾病的实验室依据。

Analysis of diagnosis value of CD64,CRP,IL-6 in pediatric infectious diseases

Objective To investigate the application of the neutrophil cell surface markers CD64,CRP,IL-6 in pediatric infectious diseases. Methods From October 2007 to October 2011 pediatric wards (including NICU hospitalization) 116 cases were divided into severe infection(49 cases),general infection( 36 cases),non-infectious(31 cases). CD64,CRP,IL-6 levels in 3 groups were measured and compared. Results CD64 as a result of severe infection group (6262.24±3776.43) molecules / cell,infection group (3727.24±1276.32) molecules/cell,non-infected group (2176.19±946.32) molecules/cell,levels of CD64 in severe infection group was significantly higher than the other two groups,CD64 value was significant difference in three groups (P<0.01). The best critical value of CD64 was 2587 molecules/cell,the diagnostic sensitivity of severe infection with 89.21% and a specificity of 78.35%; diagnostic sensitivity of 67.51% for all infections,a specificity of 82.45%. Conclusion CD64 levels are significantly increased during bacterial infection,particularly during systemic bacterial infection,and comparing to CRP,IL-6,the diagnostic superiority is more obvious,especially for children with severe infection,it can be as laboratory evidence of early diagnosis for pediatric infectious diseases.