血清OCIF水平与2型糖尿病骨代谢关系初探

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)血清破骨细胞生成抑制因子(osteoclastogenesis inhibitoryfactor,OCIF)/骨保护素(osteoprotegerin,OPG)的变化及与骨密度(bone mineral density,BMD)、骨代谢生化指标的关系.方法对60例T2DM患者及30例正常人用酶联免疫吸附法测定血清OCIF,同时测定血清骨钙素(osteocalcin BGP)、尿脱氧吡啶啉(deoxypyridinoline,DPD)、血糖、血钙、磷、碱性磷酸酶和桡骨BMD.结果无论糖尿病组或对照组,血清OCIF水平均随年龄增加而增加,尤其在60岁组增加明显;除70岁组男性较女性增高外,其余各组无明显差异;糖尿病组血清OCIF较对照组增高(P＜0.01),伴骨质疏松组较骨量正常组低(P＜0.05);血清OCIF与年龄、BMD、BGP呈正相关,与尿DPD呈负相关.结论血清OCIF不足或相对缺乏是糖尿病骨质疏松的重要因素之一;提示血清OCIF检测可作为糖尿病骨质疏松诊断的重要参考指标.

Relationship between serum OCIF level and bone metabolism index of type 2 diabetes patients

Objective To study the relationship of the changes of serum osteoclastogenesis inhibitory factor (OCIF) / osteoprotegerin (OPG) level with bone mineral density (BMD) and biochemical index of bone metabolism in type 2 diabetes mellitus (T2DM) patients. Methods The levels of OCIF, serum osteocalcin (BGP), urinary deoxypyridinoline (DPD), blood glucose, serum calcium, phosphorus, alkaline phosphatase, and radius BMD in 60 T2DM patients and 30 normal controls were detected by enzyme linked immunosorbent assay. Results Serum OCIF levels in both diabetes group and control increased in an age dependent manner, especially significantly in the group of older than 60 years. In 70 years old group, the serum OCIF level in males was higher than that in females, but in the rest groups, no significant difference was found. Serum OCIF level in diabetes group was significantly higher than that in the control ( P <0.01), but the serum OCIF level in diabetes group with osteoporosis was significantly lower than that in group of normal bone mineral density ( P <0.05). The serum OCIF level was positively correlated with age, BMD, and BGP, but negatively with urinary DPD. Conclusion Serum OCIF may play an important role in the genesis and progress of diabetes with osteoporosis. OCIF shortage or relative deficiency may be a main reason for diabetic osteoporosis. Serum OCIF level can be used as one of the important reference indices for the diagnosis of diabetic osteoporosis.