| 急慢性乙肝病毒感染者肝内HLA-DR抗原的免疫组化研究 |
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| 引用本文： | 郝连杰,江圣勇. 急慢性乙肝病毒感染者肝内HLA-DR抗原的免疫组化研究[J]. 华中科技大学学报(医学版), 1990, 0(2) |
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| 作者姓名： | 郝连杰 江圣勇 |
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| 作者单位： | 同济医科大学附属同济医院临床免疫研究室(郝连杰)，同济医科大学附属同济医院临床免疫研究室(江圣勇) |
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| 基金项目： | “七·五”期间国家重点科技攻关项目，国家自然科学基金委员会资助 |
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| 摘 要： | 对95例急慢性HBV感染者应用免疫组化方法证实:28例(29.5％)患者的肝内检出HLA-DR抗原的肝细胞膜表达,表达HLA-DR抗原的肝细胞呈灶性和片状分布,常有较明显的水样变性,且与肝内HBcAg的存在有关。结果提示,HLA-DR抗原的膜表达可能与肝细胞损伤有关。
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| 关 键 词： | 乙肝病毒感染 HLA-DR抗原 HBeAs/HBeAb HBcAg 免疫组织化学 |
An Immunohistochemical Study of the Intrahepatic HLA-DR Antigen in the Patients with Acute or Chronic Hepatitis B Virus Infection |
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| Hao Lianjie,Jiang ShengyongClinical Immunology Research Laboratory,Tongii Hospital,Tongii Medical University,Wuhan. An Immunohistochemical Study of the Intrahepatic HLA-DR Antigen in the Patients with Acute or Chronic Hepatitis B Virus Infection[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1990, 0(2) |
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| Authors: | Hao Lianjie Jiang ShengyongClinical Immunology Research Laboratory Tongii Hospital Tongii Medical University Wuhan |
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| Abstract: | Intrahepatic expression of HLA-DR antigen in 95 patients with acute and chronic hepatitis B virus infection was investigated.Hepatocyte membrane expression of HLA-DR antigens was detected in 4 cases with acute hepatitis,22 with chronic active hepatitis and 2 with active liver cirrhosis.They were distributed as focal and flaky patterns and often showed marked ballooning degeneration,thus relating to expression of HBcAg in the liver.These results suggest that membranous expression of HLA-DR antigen may be associated with hepatic injury. |
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| Keywords: | Hepatitis B virus infection. HLA-DR antigen HBeAg/HBeAb HBcAg immunohistochemistry |
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