| 基因重组人骨形成蛋白-2和聚乳酸复合异位诱导成骨的实验研究 |
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| 引用本文： | 程祥荣,杜兵,徐东选. 基因重组人骨形成蛋白-2和聚乳酸复合异位诱导成骨的实验研究[J]. 口腔医学研究, 2002, 18(6): 387-389 |
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| 作者姓名： | 程祥荣 杜兵 徐东选 |
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| 作者单位： | 武汉大学口腔医学院,湖北,武汉,430079 |
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| 摘 要： | 目的：观察基因重组人骨形成蛋白－2（recombinant human Bone Morphofenetic protein-2,rhBMP-2)和聚乳酸（Polylactic acid,PLA)复合形成的活性涂层种植体的异位诱导成骨活性。方法：将rhBMP-2与聚乳酸复合，构建活性涂层种植体，植入兔肌内，于1，4，8周后进行X线、大体观察及组织学观察，检测异位成骨活性。结果：rh-BMP-2/PLA活性复合涂层种植体具有骨诱导能力，PLA为rhBMP-2的良好控释载体。结论：rhBMP-2/PLA涂层具有良好的生物相容性和骨诱导活性，是一种理想的种植体涂层形成。
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| 关 键 词： | 基因重组人骨形成蛋白－2 聚乳酸 复合异位诱导成骨 实验研究 |
| 文章编号： | 1671-7651(2002)06-0387-03 |
| 修稿时间： | 2002-07-04 |
Experimental Research of Ectopic Osteoinductive Activity of rhBMP-2/PLA Composite as a New Kind of Implant Coating Material |
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| CHENG Xiang-rong,DU Bing,XU Dong-xuan.Stomatological college and hospital of wuhan University,Wuhan. Experimental Research of Ectopic Osteoinductive Activity of rhBMP-2/PLA Composite as a New Kind of Implant Coating Material[J]. Journal of Oral Science Research, 2002, 18(6): 387-389 |
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| Authors: | CHENG Xiang-rong DU Bing XU Dong-xuan.Stomatological college hospital of wuhan University Wuhan |
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| Affiliation: | CHENG Xiang-rong,DU Bing,XU Dong-xuan.Stomatological college and hospital of wuhan University,Wuhan 430079 |
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| Abstract: | Objective:To study the ectopic osteoinductive activity of rhBMP-2/PLA coated implants.Methods:rhBMP-2/PLA coated implants were implanted into the muscle pouches of rabbits.After 1,4,8 weeks,ectopic osteoinductive activity of rhBMP-2 was examined by X ray ?naked eyes and histology.Results:rhBMP-2/PLA coated implant has the osteoinductive activity.PLA could be used as a good carrier and control the release of rhBMP-2.Conclusions:rhBMP-2/PLA coating posses definitive biocompatibility and osteoinductivity ,and may be an ideal type of implant coating. |
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| Keywords: | rhBMP-2 PLA Controlled release framework Ectopic osteoinductive activity |
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