维持性血液净化患者微炎症状态的临床研究

目的：观察血液透析患者与腹膜透析患者微炎症状态存在情况,比较两种不同类型血液净化治疗微炎症状态的差别。方法：选择我院透析中心血液透析患者58例,腹膜透析患者49例,健康对照组57例,空腹采取静脉血检测超敏CRP（hs-CRP）、IL-6、IL-8、TNF-α,比较各组数值的情况。结果：血液透析组、腹膜透析组超敏CRP（hs-CRP）、IL-6、TNF-α均高于健康对照组（P〈0.05）;IL-8均高于对照组,但无统计学差异（P〉0.05）。血液透析组与腹膜透析组比较,超敏CRP（hs-CRP）高于腹膜透析组（P〈0.05）;两组比较IL-6、IL-8、TNF-α均无统计学差异。结论：血液透析、腹膜透析患者均存在较高的微炎症状态,两者相比血液透析患者微炎症状态高于腹膜透析,但腹膜透析患者的前炎症因子与血液透析水平相同。

Clinical Study on Micro Inflammatory State in Maintain blood Purification

Objective：To compare with the different micro inflammatory states in maintenance hemodialysis patients and peritoneal dialysis patients, to compare the difference in these two groups.Methods：This study included 58 HD patients and, 49 PD patients and 57 normal controls, use hs-CRP,IL-6, IL-8, TNF-αwith empty stomach and venous-blood-detect,and then compare every group’s number.Results：the levels of inflammatory cytokines （hs-CRP, IL-6, TNF-α） in maintenance hemodialysis patiests and dialysis patients were much higher than those in health control group.IL-8 was higher too, but no signifigance was found. Hs-CRP in HD patients was higher than that in PD patients （P〈0.05）, but there was no significance of IL-6, TNF-α,IL-8.Conclusion：There exists a rasied inflammatory cytokines levels in maintenance hemodialysis patients and PD patients, the inflammatory cytokines（hs-CRP） in HD is higher than in PD,but the proinflammatory cytokines（IL-8,IL-6,TNF-α） were in the same level.